AI Article Synopsis
- - The translocation (8;21)(q22;q22) is commonly linked with the M2 subtype of Acute Myeloid Leukemia (AML), as noted in this case study.
- - A nine-year-old boy diagnosed with AML-M2 exhibited no typical symptoms like enlarged liver or spleen, swollen lymph nodes, or bleeding issues.
- - Bone marrow analysis revealed a significant presence (60%) of eosinophilic precursors, and cytogenetic testing confirmed the (8;21) translocation, indicating eosinophils may play a role in the leukemic process.
Article Abstract
The translocation (8;21)(q22;q22) is frequently associated with M2 subtype of AML. The authors herein present a case of AML-M2 in a nine-year-old boy without hepatosplenomegaly, lymphadenopathy or any bleeding diathesis. Bone marrow examination revealed high number of eosinophilic precursors (60%) among the total nucleated bone marrow cells. Cytogenetic study with G- banding method showed 46, XY, t (8;21)(q22;q22). The morphological abnormalities in eosinophils observed in AML suggested that eosinophils may be a part of leukemic process.
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| http://dx.doi.org/10.1007/s12098-011-0481-2 | DOI Listing |
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