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Perivascular Macrophages Convert Physical Wound Signals Into Rapid Vascular Responses.
bioRxiv
December 2024
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Leukocytes detect distant wounds within seconds to minutes, which is essential for effective pathogen defense, tissue healing, and regeneration. Blood vessels must detect distant wounds just as rapidly to initiate local leukocyte extravasation, but the mechanism behind this immediate vascular response remains unclear. Using high-speed imaging of live zebrafish larvae, we investigated how blood vessels achieve rapid wound detection.
View Article and Find Full Text PDFALOX15-Driven Ferroptosis: The key target in Dihydrotanshinone I's epigenetic Battle in hepatic stellate cells against liver fibrosis.
Int Immunopharmacol
December 2024
Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:
Background: It is known that ferroptosis promotes hepatic stellate cells (HSCs) inactivation. Arachidonate 15-Lipoxygenase (ALOX15), a ferroptosis driver gene, participates in disease progression.
Purpose: Dihydrotanshinone I (DHI), an active compound from Salvia miltiorrhiza, effectively regulates HSC inactivation.
[Retracted] Inhibition of 5‑lipoxygenase triggers apoptosis in pancreatic cancer cells.
Oncol Rep
February 2025
Department of Gastroenterology, Affliliated Hospital of Nantong University, Jiangsu, Nantong 226001, P.R. China.
Following the publication of the above paper, a concerned reader drew to the Editor's attention that Fig. 3 on p. 664, showing TUNEL assay data relating to apoptosis of the cell line under investigation in this paper, contained apparent anomalies, including repeated patternings of certain cells both within and between the data panels, such that it would have been difficult to have attributed these anomalies to coincidence.
View Article and Find Full Text PDFBaicalein blocked gastric cancer cell proliferation and invasion through modulated platelet type 12-lipoxygenase.
Iran J Basic Med Sci
January 2024
Cancer Research Center, Yanbian University Medical College, Key Laboratory of Pathobiology (Yanbian University), State Ethnic Affairs Commission, Research and Innovation Group of Yanbian University, Yanji 133002, China.
Objectives: Baicalein (BAI) is one of the main ingredients of georgi. Its pharmacological effects have been widely reported in various cancers. However, the specific molecular mechanism of BAI in gastric cancer (GC) has not been defined.
View Article and Find Full Text PDFResearch progress on the role of lipoxygenase and its inhibitors in prostate cancer.
Future Oncol
November 2024
Chongqing Medical & Pharmaceutical College, Chongqing, 400030, China.
Prostate cancer (PCa) has become a common disease among middle-aged and elderly men. The lipoxygenase (LOX) pathway plays a crucial role in the occurrence, development, invasion and metastasis of PCa and is therefore considered a new target for the prevention and treatment of PCa. 5-LOX and 12-LOX have a promoting effect on the occurrence, development, invasion and metastasis of PCa.
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