Background: Polyethylene glycol (PEG) is a commonly used bowel preparation for colonoscopy. Unfortunately, the standard large-volume solution may reduce patient compliance. Split-dosing of PEG has been studied in various randomized, controlled trials (RCTs). However, results have been conflicting.
Objective: We conducted a meta-analysis to assess the role of split-dose PEG versus full-dose PEG for bowel preparation before colonoscopy.
Design: Multiple databases were searched (January 2011). RCTs on adults comparing full-dose and split-dose of PEG for bowel preparation before colonoscopy were included and analyzed by calculating pooled estimates of quality of bowel preparation, preparation compliance, willingness to repeat the same preparation, and side effects by using odds ratio (OR) by fixed and random-effects models.
Setting: Literature search.
Patients: Per RCTs.
Main Outcome Measurements: Satisfactory bowel preparation, willingness to repeat same bowel preparation, patient compliance, and side effects.
Results: Five trials met inclusion criteria (N = 1232). Split-dose PEG significantly increased the number of satisfactory bowel preparations (OR 3.70; 95% CI, 2.79-4.91; P < .01) and willingness to repeat the same preparation (OR 1.76; 95% CI, 1.06-2.91; P = .03) compared with full-dose PEG. Split-dose PEG also significantly decreased the number of preparation discontinuations (OR 0.53; 95% CI, 0.28-0.98; P = .04) and nausea (OR 0.55; 95% CI, 0.38-0.79; P < .01) compared with full-dose PEG.
Limitations: Limited number of studies.
Conclusions: The use of a split-dose PEG for bowel preparation before colonoscopy significantly improved the number of satisfactory bowel preparations, increased patient compliance, and decreased nausea compared with the full-dose PEG.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.gie.2011.02.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Direct analysis and identification of the intestinal microflora of shrimps for their geographical traceability mass spectrometry and bacterial library searching.
Analyst
January 2025
College of Food Science and Technology, Shanghai Ocean University (SHOU), 999 Hucheng Ring Road, Pudong New District, 201306 Shanghai, China.
The expansion of the seafood market has led to an increased probability of food fraud. The development of rapid and reliable traceability methods for aquatic food products is of utmost importance. In this study, direct analysis and identification of the intestinal microbiota of aquatic foods were conducted.
View Article and Find Full Text PDFAuthor's reply: Comment on "comparative efficacy of different bowel preparations for colonoscopy: A network meta-analysis".
Dig Liver Dis
January 2025
Gastroenterology Unit, Department of Experimental Medicine, University of Salento, Lecce, Italy; Clinical Effectiveness Research Group, University of Oslo, Oslo, Norway.
High risk and low incidence diseases: Stercoral colitis.
Am J Emerg Med
January 2025
Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, TX, United States of America.
Introduction: Stercoral colitis is a rare but serious diagnosis which is associated with a high rate of morbidity.
Objective: This review highlights the pearls and pitfalls of stercoral colitis, including presentation, diagnosis, and emergency department (ED) management based on the available evidence.
Discussion: Stercoral colitis is an uncommon inflammatory condition of the distal large bowel and rectum resulting from accumulation of impacted stool and is associated with several complications including bowel ulceration, ischemia, perforation, peritonitis, and sepsis.
General Versus Interventional Gastroenterologists: A Comparative Analysis of Follow-Up Outcomes After Endoscopic Mucosal Resection of Colorectal Polyps.
Cureus
December 2024
Gastroenterology and Hepatology, Washington University in St. Louis, St. Louis, USA.
Introduction Colorectal cancer (CRC) represents a major global health burden, significantly impacting mortality rates and healthcare systems worldwide. CRC screening through colonoscopy enables early detection and removal of precancerous polyps. While standard polypectomy suffices for small polyps, larger ones require endoscopic mucosal resection (EMR).
View Article and Find Full Text PDFCan Artificial Intelligence Create an Accurate Colonoscopy Bowel Preparation Prompt?
Gastro Hep Adv
October 2024
Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, Mount Sinai South Nassau, One Healthy Way, Oceanside, New York.
Background And Aims: Colorectal cancer is the third most common cancer in the United States, with colonoscopy being the preferred screening method. Up to 25% of colonoscopies are associated with poor preparation which leads to prolonged procedure time, repeat colonoscopies, and decreased adenoma detection. Artificial intelligence (AI) is being increasingly used in medicine, assessing medical school exam questions, and writing medical reports.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!