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Metabolic Features of Assigned Female at Birth Transgender People on Gender-Affirming Hormone Therapy: A Meta-analysis.
Transgend Health
December 2024
Andrology Unit, Department of Clinical Medicine, Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Purpose: There is a paucity of data on the safety and efficacy of long-term testosterone (T)-based gender-affirming hormone therapy (GAHT) on anthropometric parameters, body composition, and glycolipid metabolism in assigned female at birth (AFAB) persons. The purpose of this study was to provide an updated meta-analysis on this topic.
Methods: We searched PubMed, Scopus, and Cochrane Library for relevant studies.
Iron-sulfur cluster redox chemistry and dimer dissociation in the outer mitochondrial membrane protein, mitoNEET.
J Biol Inorg Chem
December 2024
Department of Chemistry and Biochemistry, University of Toledo, Toledo, OH, USA.
The outer mitochondrial membrane protein known as mitoNEET was discovered when it was labeled by a photoaffinity derivative of the anti-diabetes medication, pioglitazone. The biological role for mitoNEET and its specific mechanism for achieving this remains an active subject for research. There is accumulating evidence suggesting that mitoNEET could be a component of mitochondrial FeS cofactor biogenesis.
View Article and Find Full Text PDFReconstructive Surgery in the Elderly: A Case Report on Maintaining the Quality of Life in a Patient with Vulvar Dermatofibrosarcoma Protuberans.
Diseases
November 2024
Department of Gynecology and Gynecologic Oncology, Medical University of Białystok, Skłodowskiej Str. 24A, 15-276 Białystok, Poland.
Background: Dermatofibrosarcoma protuberans (DFSP) is a rare proliferative condition representing skin sarcomas known to locally recur yet very rarely known to metastasize. A typical characteristic is trunk localization, making vulvar occurrences an exception. Complete resection is the primary treatment.
View Article and Find Full Text PDFRedescription of Oshmarin & Demshin, 1972 (Heterakidae: Meteterakinae) from a geoemydid tortoise in China with comments on the genus.
J Helminthol
December 2024
A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Leninskii prospect 33, Moscow, 119071, Russian Federation.
Oshmarin & Demshin, 1972 is redescribed from the posterior intestine of tropical tortoise (Gmelin, 1789) (Testudines: Geoemydidae) from China. Some characteristic features of the male reproductive system not reported previously are now reported for the present species. These include the presence of two blind diverticula near the mid-region of the seminal vesicle and a small cuticular structure near the opening of the cloaca - which we propose to name the 'scutum.
View Article and Find Full Text PDFBrain energy homeostasis: the evolution of the astrocyte-neuron lactate shuttle hypothesis.
Korean J Physiol Pharmacol
January 2025
Department of Physiology, Ajou University School of Medicine, Suwon 16499, Korea.
The brain's substantial metabolic requirements, consuming a substantial fraction of the body's total energy despite its relatively small mass, necessitate sophisticated metabolic mechanisms for efficient energy distribution and utilization. The astrocyte-neuron lactate shuttle (ANLS) hypothesis has emerged as a fundamental framework explaining the metabolic cooperation between astrocytes and neurons, whereby astrocyte-derived lactate serves as a crucial energy substrate for neurons. This review synthesizes current understanding of brain energy metabolism, focusing on the dual roles of lactate as both an energy substrate and a signaling molecule.
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