AI Article Synopsis
- Hypoxia in solid tumors triggers intracellular reactions involving hypoxia-inducible factors, HIF-1 and HIF-2, leading to overexpression in these tumors.
- Overexpression of HIF is linked to resistance against chemotherapy and radiation in many cancer patients.
- Researchers are exploring various drugs that can inhibit pathways leading to HIF activation, with clinical trials currently underway to test their effectiveness.
Article Abstract
Hypoxia that originates from disturbed growth of solid tumors initiates a cascade of intracellular events engaging hypoxia-inducible factors, HIF-1 and HIF-2. Overexpression of HIF has been confirmed in solid tumors and was unfortunately accompanied with chemo- and radioresistance observed in many patients. Multiple cellular pathways resulting in HIF activation could be successfully inhibited by use of different kinds of drugs (e.g. topotecan, heat shock protein 90 and mTOR inhibitors, YC-1, pleurotin or 2-methoxyestradiol), which are being subjected into intensive investigation in clinical trials.
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| http://dx.doi.org/10.1007/s00005-011-0132-3 | DOI Listing |
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