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Early, Individualized Recommendations for Hospitalized Patients With Acute Kidney Injury: A Randomized Clinical Trial.
JAMA
December 2024
Clinical and Translational Research Accelerator, Yale University, New Haven, Connecticut.
Importance: Acute kidney injury (AKI) is a common complication during hospitalization and is associated with adverse outcomes.
Objective: To evaluate whether diagnostic and therapeutic recommendations sent by a kidney action team through the electronic health record improve outcomes among patients hospitalized with AKI compared with usual care.
Design, Setting, And Participants: Randomized clinical trial conducted at 7 hospitals in 2 health systems: in New Haven, Bridgeport, New London, and Waterbury, Connecticut, and Westerly, Rhode Island; and in Baltimore, Maryland.
The early diagnostic value of serum renalase level in diabetic kidney disease and diabetic macroangiopathy: a retrospective case-control study.
Ther Adv Chronic Dis
October 2024
Shanghai Diabetes Institute, Shanghai Key Clinical Center for Metabolic Diseases, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Background: Diabetic kidney disease (DKD) is a severe complication of diabetes mellitus and is associated with an increased risk of end-stage renal disease (ESRD) and cardiovascular events. Early diagnosis and monitoring of DKD are crucial for implementing appropriate interventions. This study aimed to investigate the relationship between serum renalase (RNLS) levels, DKD, and diabetic macroangiopathy in patients with type 2 diabetes mellitus (T2DM).
View Article and Find Full Text PDFRenalase rs2296545 variant improve hypertension susceptibility by modifying binding affinity to catecholamines in obstructive sleep apnea.
Hypertens Res
November 2024
Central Laboratory of Shanghai Eighth People's Hospital, Xuhui Branch of Shanghai Sixth People's Hospital, Caobao Road 8, Shanghai, 200235, China.
Article Synopsis
- Obstructive sleep apnea (OSA) is linked to high blood pressure (hypertension) and researchers studied a protein called renalase to understand this connection in a Chinese population.
- They found that people with severe OSA had higher levels of renalase in their blood, and those levels affected blood pressure differently depending on whether someone had OSA or not.
- A specific genetic variation known as rs2296545 was also found to increase the risk of hypertension in people with severe OSA by changing how well renalase interacts with other important chemicals in the body.
Cardiovascular Risk in Pediatric Renal Transplant Recipients.
Pediatr Transplant
November 2024
Pediatric Kidney Transplantation Department, Hospital Samaritano de São Paulo, São Paulo, Brazil.
Background: The survival of pediatric chronic kidney disease (CKD) patients has improved in recent decades due to advances in dialysis and transplantation. However, cardiovascular disease (CVD) emerges as the main cause of mortality in patients with CKD.
Objectives: To estimate cardiovascular risk in children with CKD at least 1 year after kidney transplantation.
The utility of urine sodium-guided diuresis during acute decompensated heart failure.
Heart Fail Rev
November 2024
Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Article Synopsis
- Diuresis is crucial for treating patients with acute decompensated heart failure (ADHF) to relieve fluid buildup, but there's no one-size-fits-all diuretic strategy that has proven to be the best.
- Current research highlights the connection between urine sodium levels and patient outcomes, suggesting that monitoring urine chemistry could help tailor diuretic treatments.
- The review aims to consolidate existing studies on diuretic management, identify what we still don't know, and outline ongoing clinical trials that explore urine sodium-guided diuresis in ADHF management.
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