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A Model for Consolidating High-Risk Allergy Procedures in Clinic.
Ochsner J
January 2024
Department of Allergy and Immunology, Ochsner Clinic Foundation, New Orleans, LA.
Allergists perform a range of procedures with inherent risks of anaphylaxis. This study developed risk assessments for various procedures performed at our specialized referral center based on the frequency of epinephrine use during these procedures. During a 5.
View Article and Find Full Text PDFNonclinical safety and immunogenicity assessment of a combined DTacP vaccine in animal models.
J Appl Toxicol
November 2024
Beijing Institute of Biological Products Company Limited, Beijing, China.
The (diphtheria, tetanus, and pertussis [acellular, component] [DTacP]) vaccine is a combined vaccine designed to prevent three potentially fatal diseases including pertussis, tetanus, and diphtheria in both children and adults. We utilized advanced technology to develop a novel DTacP vaccine that was previously unavailable in China. The nonclinical studies were performed to evaluate the immunogenicity, potential toxicity, and local tolerance of the vaccine in animal models.
View Article and Find Full Text PDFMast Cell Interaction with Foxp3 Regulatory T Cells Occur in the Dermis after Initiation of IgE-Mediated Cutaneous Anaphylaxis.
Cells
September 2022
Institut Necker Enfants Malades, Centre National de la Recherche Scientifique UMR 8253, Université Paris Cité, Institute National de la Santé et de la Recherche Médicale U1151, 75020 Paris, France.
Mast cells (MCs) are well-known for their role in IgE-mediated cutaneous anaphylactic responses, but their regulatory functions in the skin are still under intense scrutiny. Using a Red MC and Basophil reporter (RMB) mouse allowing red fluorescent detection and diphtheria toxin mediated depletion of MCs, we investigated the interaction of MCs, Foxp3 regulatory T lymphocytes (Tregs) and Langerhans cells (LCs) during passive cutaneous anaphylaxis (PCA) responses. Using intravital imaging we show that MCs are sessile at homeostasis and during PCA.
View Article and Find Full Text PDFNew inducible mast cell-deficient mouse model (Mcpt5/Cma1).
Biochem Biophys Res Commun
April 2021
School of Veterinary Medicine, Kitasato University, Towada, 034-8628, Japan. Electronic address:
Mast cell-deficient mice are helpful for understanding the roles of mast cells in vivo. To date, a dozen mouse models for mast cell deficiency have been reported. However, mice with a specific depletion of all populations of mast cells have not been reported.
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