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Resolving heterogeneity of early-onset major depressive disorder through individual differential structural covariance network analysis.
J Affect Disord
January 2025
Department of Child and Adolescent Psychiatry, Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China; The First School of Clinical Medicine, Southern Medical University, Guangzhou, China; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China; Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China. Electronic address:
Background: Early-onset major depressive disorder (EO-MDD) is characterized by its significant heterogeneity, hindering progress in research. Traditional case-control studies, like group-level structural covariance network, struggle to capture individual heterogeneity among EO-MDD patients.
Methods: In this study, T1-weighted structural magnetic resonance imaging was obtained from 185 participants, including 103 EO-MDD patients and 82 healthy controls.
PTSD and CPTSD in the new ICD-11 - A latent profile analysis.
Psychiatry Res
January 2025
Clinic for Psychosomatic Medicine and Psychotherapy, University of Duisburg-Essen, LVR-University Hospital Essen, Essen, Germany; Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University of Duisburg-Essen, Essen, Germany.
In the 11th version of the WHO´s International Classification of Diseases, complex post-traumatic stress disorder (CPTSD) is newly recognized as a variant of PTSD, characterized by additional and more severe symptoms and typically arising from prolonged or multiple traumatic experiences. Despite recent research supporting the differentiation between PTSD and CPTSD, studies also identify a third or even a fourth latent profile in trauma patients. This study employs latent profile analysis to identify the number of latent profiles within a clinical trauma population in Germany (N = 588) and aims to investigate their distinct symptomatology.
View Article and Find Full Text PDFHead-to-Head Comparison of Aptamer- and Antibody-Based Proteomic Platforms in Human Cerebrospinal Fluid Samples from a Real-World Memory Clinic Cohort.
Int J Mol Sci
December 2024
Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.
High-throughput proteomic platforms are crucial to identify novel Alzheimer's disease (AD) biomarkers and pathways. In this study, we evaluated the reproducibility and reliability of aptamer-based (SomaScan 7k) and antibody-based (Olink Explore 3k) proteomic platforms in cerebrospinal fluid (CSF) samples from the Ace Alzheimer Center Barcelona real-world cohort. Intra- and inter-platform reproducibility were evaluated through correlations between two independent SomaScan assays analyzing the same samples, and between SomaScan and Olink results.
View Article and Find Full Text PDFMedication use is associated with distinct microbial features in anxiety and depression.
Mol Psychiatry
January 2025
Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
This study investigated the relationship between gut microbiota and neuropsychiatric disorders (NPDs), specifically anxiety disorder (ANXD) and/or major depressive disorder (MDD), as defined by Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV or V criteria. The study also examined the influence of medication use, particularly antidepressants and/or anxiolytics, classified through the Anatomical Therapeutic Chemical (ATC) Classification System, on the gut microbiota. Both 16S rRNA gene amplicon sequencing (16S) and shallow shotgun sequencing (WGS) were performed on DNA extracted from 666 fecal samples from the Tulsa-1000 and Neurocomputational Mechanisms of Affiliation and Personality Study Center for Biomedical Research Excellence (NeuroMAP CoBRE) cohorts.
View Article and Find Full Text PDFPerinatal mental health and risk of severe maternal morbidity in women with physical disabilities, Massachusetts 2003-2015.
Disabil Health J
January 2025
Lurie Institute for Disability Policy, Heller School for Social Policy and Management, 035 415 South Street, Brandeis University, Waltham, MA, 02454-9110, USA. Electronic address:
Background: Perinatal mental health and substance use disorders contribute to adverse maternal outcomes. Women with disabilities experience increased risk for severe maternal morbidity (SMM). No studies have examined the association between perinatal mental health and SMM risk in women with physical disabilities.
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