AI Article Synopsis
- The study compared therapeutic responses between 25 patients with anaplastic astrocytoma (AA) and 31 patients with glioblastoma multiforme (GM).
- The AA group showed a significant improvement and longer tumor-free intervals after initial treatment with radiation and nitrosourea, particularly in those with moderate cases.
- In contrast, the GM group experienced early tumor recurrence regardless of how much of the tumor was surgically removed, complicating ongoing treatment despite similar initial responses.
Article Abstract
We have investigated the differences in therapeutic efficacy between 25 cases with an anaplastic astrocytoma (AA group) and 31 cases with a glioblastoma multiforme (GM group). A good response to induction therapy was achieved with radiation and nitrosourea after a (sub) total removal that led to a prolonged tumor-free interval that was remarkable in the AA group, especially in those with moderate anaplastic astrocytoma. On the other hand, in the GM group, early recurrence tended to occur with no correlation to the degree of the tumor resection, and this made the execution of the maintenance therapy difficult in spite of a similar response to the initial induction therapy as that seen in the AA group.
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