Purpose: Laser-assisted in situ keratomileusis (LASIK) requires precise corneal flap cutting. Especially the creation of thin flaps has recently gained importance for thin-flap LASIK. Currently, there is a trend towards faster femtosecond lasers that can produce flaps in a short period of time. We analyzed flaps created with a 200-kHz femtosecond laser concerning their cut precision, morphology, and histology.
Methods: Femtosecond laser flap cutting was performed on 36 porcine cadaver eyes using the prototype 200-kHz femtosecond laser UltraFlap (WaveLight GmbH, Erlangen, Germany). The eyes were assigned to 3 thickness groups, with a cut depth of 100 µm, 130 µm, or 180 µm, respectively. Additionally, flap diameters were varied, ranging from 8.0 mm to 9.5 mm. Flap thicknesses were determined with a micrometer gauge. Flap diameters were measured with a sliding caliper. Furthermore, flaps were created for histologic examination.
Results: There were no complications during flap creation. The mean flap thickness and standard deviation was (in micrometers) 96.33 ± 7.45 (intended thickness: 100), 134.67 ± 4.96 (intended thickness: 130), and 174.59 ± 9.35 (intended thickness: 180), respectively. The flap diameter revealed a mean (in mm) of 8.03 ± 0.15 (intended diameter: 8.0), 8.56 ± 0.10 (intended diameter: 8.5), 9.09 ± 0.10 (intended diameter: 9.0), and 9.54 ± 0.15 (intended diameter: 9.5), respectively. Histologic examination showed very little to almost no changes in the structure of the corneal stroma.
Conclusions: Flap creation could be performed easily without any complications. The morphology and accuracy of the cuts were very reliable and precise. Histology showed a smooth cut.
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http://dx.doi.org/10.5301/EJO.2011.8376 | DOI Listing |
BMC Ophthalmol
December 2024
School of Medicine, Xiamen Eye Center and Eye Institute of Xiamen University, Xiamen, 361000, China.
Purepose: The intraoperative femtosecond laser time, Cumulative Dissipated Energy (CDE), Effective Phacoemulsification time (EPT), and intraoperative fluid perfusion volume were compared under different model fragmentation modes using Catalys femtosecond laser system.
Methods: This was a single-center, prospective, randomized controlled study. A total of 120 eyes who underwent femtosecond laser-assisted cataract phacoemulsification combined with intraocular lens implantation in Xiamen Eye Center affiliated to Xiamen University from September 2022 to March 2023 were randomly divided into 4 groups to undergo pre-nucleus splitting in different ways: Group 1: six-split, Group 2: eight-split, Group 3: six-split + gridded softening, and Group 4: eight-split + gridded softening.
Biosensors (Basel)
November 2024
Institute of Laser Engineering, Osaka University, Suita 565-0871, Osaka, Japan.
Biosensors operating in the terahertz (THz) region are gaining substantial interest in biomedical analysis due to their significant potential for high-sensitivity trace-amount solution detection. However, progress in compact, high-sensitivity chips and methods for simple, rapid and trace-level measurements is limited by the spatial resolution of THz waves and their strong absorption in polar solvents. In this work, a compact nonlinear optical crystal (NLOC)-based reflective THz biosensor with a few arrays of asymmetrical meta-atoms was developed.
View Article and Find Full Text PDFAdv Mater
December 2024
School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong (CUHK-Shenzhen), Shenzhen, Guangdong, 518172, P. R. China.
The existence of residual small-size tumors after surgery is a major factor contributing to the high recurrence rate of glioblastoma (GBM). Conventional adjuvant therapeutics involving both chemotherapy and radiotherapy usually exhibit unsatisfactory efficacy and severe side effects. Recently, two-photon photodynamic therapy (TP-PDT), especially excited by the second near-infrared (NIR-II) light, offers an unprecedented opportunity to address this challenge, attributed to its combinational merits of PDT and TP excitation.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
Institute of Materials Science and Engineering, Chemnitz University of Technology, Erfenschlager Straße 73, Chemnitz 09125, Germany.
The generation of laser-induced periodic surface structures (LIPSS) using femtosecond lasers facilitates the engineering of material surfaces with tailored functional properties. Numerous aspects of their complex formation process are still under debate, despite intensive theoretical and experimental research in recent decades. This particularly concerns the challenge of verifying approaches based on electromagnetic effects or hydrodynamic processes by experiment.
View Article and Find Full Text PDFAnal Chem
December 2024
State Key Laboratory of Continental Dynamics, Department of Geology, Northwest University, Xi'an 710069, China.
Matrix effects can significantly bias Hf isotopic ratios in situ Hf isotope analyses using laser ablation (LA-) multicollector inductively coupled plasma mass spectrometry (MC-ICP-MS), necessitating the use of matrix-matched reference materials for accurate microanalysis. This work introduces a novel fast hot-pressing (FHP) sintering method to produce such reference materials efficiently for in situ analysis. By optimizing sintering temperatures, FHP technology enables the rapid preparation of in situ analysis reference materials with dense structures and homogeneous Hf isotopic compositions.
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