AI Article Synopsis
- * This study analyzed HPV presence in 59 women with histologically confirmed VIN, finding a high infection rate of 79.6%, primarily featuring HPV types 16, 33, 6, and 42.
- * Notably, 63% of cases were associated with HPV types 16/18, which are covered by existing HPV vaccines, and HPV-positive women tended to be younger than their HPV-negative counterparts.
Article Abstract
Vulval intraepithelial neoplasia is a precursor of vulval carcinoma, and is frequently associated with human papillomavirus (HPV) infection. Estimates of HPV prevalence in vulval intraepithelial neoplasia vary widely in the UK. The objective of this study was to assess HPV infection in a sample of women with vulval intraepithelial neoplasia, confirmed histologically, and determine the proportion of disease associated with HPV types targeted by prophylactic HPV vaccines. HPV infection was assessed in biopsies from 59 patients using the Greiner Bio-One PapilloCheck® DNA chip assay. Valid results were obtained for 54 cases. HPV infection was present in 43 of the 54 cases (79.6%: 95% CI 67.1-88.2%). The most common HPV types were HPV 16 (33/54: 61.1%), HPV 33 (8/54: 14.8%), HPV 6 (5/54: 9.3%), and HPV 42 (3/54: 5.6%). The mean age of HPV positive women was significantly less than the mean age of HPV negative women. This is the largest UK series of vulval intraepithelial neoplasia in which HPV type has been investigated, and 34/54 (63.0%, 95% CI: 49.6-78.6%) cases were associated with HPV 16/18, which are targeted by current prophylactic HPV vaccines.
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| http://dx.doi.org/10.1002/jmv.22107 | DOI Listing |
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Article Synopsis
- HPV-independent squamous cell carcinomas are the most common type of vulvar cancer, but their precancerous lesions are infrequently seen in clinical practice.
- Differentiated vulvar intraepithelial neoplasia (dVIN) is the main precancerous lesion associated with a high risk of progression and is often linked to lichen sclerosus, with a significant number showing TP53/p53 abnormalities.
- The review discusses various related lesions and emphasizes updates in terminology, diagnostics, biomarkers, and the underlying processes of these precancerous conditions.
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