We prepared new 7-hydroxyguanine derivatives, 7-hydroxyguanosine 5'-monophosphate and N2-tetrahydropyranyl-7-hydroxyguanine, and compared biological activities of 7-hydroxyguanine derivatives including nucleosides acquired previously. 7-Hydroxyguanine and its nucleotide inhibited the focus formation of Rous sarcoma virus. Antitumor activities of these derivatives against mouse leukemia L1210 were not so different from one another. Anti-proliferative activities of the derivatives on various human cell lines were significantly different from one another.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.7164/antibiotics.43.352 | DOI Listing |
Publication Analysis
Top Keywords
7-hydroxyguanine derivatives
12
biological activities
8
activities derivatives
8
derivatives
5
preparation 7-hydroxyguanine
4
derivatives biological
4
activities
4
activities prepared
4
prepared 7-hydroxyguanine
4
derivatives 7-hydroxyguanosine
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!