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A self-immolative Kdn-glycoside substrate enables high-throughput screening for inhibitors of Kdnases.
Glycobiology
January 2025
Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada.
Aspergillus fumigatus, a filamentous fungus, is an opportunistic pathogen and the major causative agent of the often-fatal disease, invasive aspergillosis (IA). Current treatments for IA are limited due to their high toxicity and/or the emergence of drug resistance; therefore, a need exists for the development of new therapeutics to treat IA. The Kdnase produced by A.
View Article and Find Full Text PDFImpact of catastrophic brain injury guidelines on organ donation rates: Results of an EAST multicenter trial.
J Trauma Acute Care Surg
January 2025
From the Department of Surgery (K.D.N., D. Tatum, A.P., J.C.D., A.S.A., E.I., B.M., E.C., S.T.), Tulane University School of Medicine, New Orleans, Louisiana; Department of Surgery (K.D.N.), Harbor-UCLA Medical Center, Torrance, California; Department of Surgery (M.B.P., A.W.M., A.B.P.), Vanderbilt University Medical Center, Nashville, Tennessee; Department of Surgery (J.N., C.A.), University of California-Irvine, Orange, California; Department of Surgery (P.O.U., A. Stiles, C.S.), Wake Med, Raleigh, North Carolina; Department of Surgery (J.D. Stodghill, T.M.), Virginia Tech Carilion School of Medicine, Roanoke, Virginia; Department of Surgery (R.M.B., S.A.Z., B. Shammassian, A.A.S.), Louisiana State University Health, New Orleans, Louisiana;Department of Surgery (T.E., I.A., P.M., J. Metheny), Cooper Medical School of Rowan University, Camden, New Jersey; Department of Surgery (M.S.F., M.D.P.), Lehigh Valley Health Network, Allentown, Pennsylvania; Department of Surgery (O.T.M., P.S.), Valleywise Health Medical Center, Phoenix, Arizona; Department of Surgery (D.T.-W.W., J.S.), Arrowhead Regional Medical Center, Colton, California; Department of Surgery (J.D. Sciarretta, P.K.), Emory University School of Medicine, Atlanta, Georgia; Department of Surgery (R.H., D.G.), Loma Linda University Medical Center, Loma Linda, California; Department of Surgery (J. Murry, K. Meadows), UT Health Tyler, Tyler, Texas; Department of Surgery (L.E.J., J.M.W.), Ascension St. Vincent Hospital, Indianapolis, Indiana; Department of Surgery (A.C.B.), University of Kentucky Healthcare, Lexington, Kentucky;17 DeBusk College of Osteopathic Medicine (B. Smith), Lincoln Memorial University, Harrogate, Tennessee; Department of Surgery (S.L.M., N.P.), Conemaugh Memorial Medical Center, Johnstown, Pennsylvania; Department of Surgery (D. Tabello, E.T.), Inova Health System, Falls Church, Virginia; Department of Surgery (S.M.C., F.A.), King Saud Medical City, Riyadh, Saudi Arabia;Department of Surgery (B.S.M., M.A.W.), University of Minnesota, Minneapolis, Minnesota;22 Department of Surgery (T.H.J., G.D.), Our Lady of the Lake Regional Medical Center, Baton Rouge, Louisiana;23 Department of 'Surgery (J.A.M., D.R.), Thomas Jefferson University Hospital, Philadelphia, Pennsylvania;24 Department of Surgery (J.M.H., K.L.), Ascension Via Christi Hospitals Wichita, Wichita, Kansas;25 Department of Surgery (K. Matsushima, S.P.), Los Angeles General Medical Center, Los Angeles, California; Department of Surgery (A. Santos, K.S.), Texas Tech University Health Science Center; Department of Surgery (C.B.), Covenant Medical Center, Lubbock, Texas; Department of Surgery (R.S., S.V.), Bronson Methodist Hospital, Kalamazoo, Michigan; Department of Surgery (R.J.J., R.C.H.), College of Medicine Chattanooga, University of Tennessee, Chattanooga, Tennessee; Department of Surgery (S.L.), Warren Alpert Medical School at Brown University, Providence, Rhode Island; Department of Surgery (N.B., W.A.), Tufts Medical Center, Boston, Massachusetts; Department of Surgery (M.J.L., H.M.), Research Medical Center, Kansas City, Missouri; Department of Surgery (R.P.D., C.A.F.), University of Texas Southwestern Medical Center, Dallas, Texas; Department of Surgery (C.A.F.), Brody School of Medicine at East Carolina, Greenville, North Carolina; Department of Surgery (W.T.H.T., Y.T.), University of Nebraska Medical Center, Omaha, Nevada; Department of Surgery (V.M., F.M.), U General University Hospital of Patras, Pio, Greece; and Department of Surgery (J.D.B., D.R.M.), Broward Health Medical Center, Fort Lauderdale, Florida.
Article Synopsis
- One third of organ donors experience catastrophic brain injury (CBI), but there’s no standardized management for traumatic CBI among trauma centers, leading to variability in practices.
- A multicenter trial involving 33 trauma centers analyzed 790 CBI patients to investigate whether institutions with CBI guidelines had higher organ donation rates.
- While centers with CBI guidelines showed greater use of certain treatments, the presence of guidelines did not significantly increase organ donation rates; however, hormone therapies were linked to a higher likelihood of donation.
Developing Method for Minor Acidic -Glycan Analysis in Mucin and Cancer Cell Samples.
J Proteome Res
October 2024
Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Higashi, Osaka 577-8502, Japan.
Minor acidic glycans, such as sulfated and phosphorylated glycans, constitute only a small fraction of biological glycome, making their analysis a considerable challenge. In this study, we developed a technique to analyze minor acidic -glycans in biological samples. First, efficient reaction conditions for the release of -glycans from the proteins were determined.
View Article and Find Full Text PDFA novel role of CD73-IFNγ signalling axis in human mesenchymal stromal cell mediated inflammatory macrophage suppression.
Regen Ther
June 2024
Manipal Institute of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Manipal 576104, Karnataka, India.
Introduction: Immunomodulation is the predominant mechanism via which Mesenchymal stromal cells (MSCs) mediate their therapeutic benefits. However, inconsistent success in numerous clinical trials warrants a better understating of the molecular mechanisms regulating their immunomodulatory properties. CD73, an ecto-5'-nucleotidase is abundantly expressed by MSCs, however its precise role in regulating their immunomodulatory properties is still elusive.
View Article and Find Full Text PDFMolecular dynamics simulations shed light into the donor substrate specificity of vertebrate poly-alpha-2,8-sialyltransferases ST8Sia IV.
Biochim Biophys Acta Gen Subj
August 2024
Univ. Lille, CNRS, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; Unité de Glycobiologie Structurale et Fonctionnelle, UMR CNRS 8576, Faculté des sciences et Technologies, Univ. Lille, 59655 Villeneuve d'Ascq, France. Electronic address:
Background: Sialic acids are essential monosaccharides influencing several biological processes and disease states. The sialyltransferases catalyze the transfer of Sia residues to glycoconjugates playing critical roles in cellular recognition and signaling. Despite their importance, the molecular mechanisms underlying their substrate specificity, especially between different organisms, remain poorly understood.
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