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http://dx.doi.org/10.1182/blood-2011-01-332031 | DOI Listing |
J Reprod Dev
December 2024
Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Insulin-like growth factor 2 (IGF2) is essential for cell growth and differentiation and functions through the IGF2 receptor (IGF2R) to regulate embryonic and placental development. Exosomes that are synthesized and released from cells and play important roles in embryogenesis and placental development rely on the IGF2R for sorting and transport. However, the role of the imprinted Igf2-Igr2r axis and exosomes in the co-regulation of early placental development remains unknown.
View Article and Find Full Text PDFSci Rep
October 2024
Department of Neuro-oncology, Cancer Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100071, China.
In recent years, CD9 has been extensively studied as a potential biomarker for cancer. However, the biological role of CD9 in gliomas remains unclear. This study investigates the function of CD9 in gliomas and its molecular mechanisms.
View Article and Find Full Text PDFInt J Mol Sci
September 2024
Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Alzheimer's disease is the most common form of dementia, characterized by the pathological accumulation of amyloid-beta (Aβ) plaques and tau neurofibrillary tangles. Triggering receptor expressed on myeloid cells 2 (TREM2) is increasingly recognized as playing a central role in Aβ clearance and microglia activation in AD. The gene transcriptional product is alternatively spliced to produce three different protein isoforms.
View Article and Find Full Text PDFEnviron Toxicol
August 2024
Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Small extracellular vesicles (sEVs) secreted by human umbilical cord have therapeutic effects on various degenerative diseases. However, the characteristics and potential functions of human umbilical cord mesenchymal stem cells (huMSCs)-derived sEVs, especially the role of premature ovarian failure (POF), are poorly understood. Here, we isolated and characterized huMSCs and their sEVs.
View Article and Find Full Text PDFMol Biotechnol
March 2024
School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
Acute pancreatitis (AP) and chronic pancreatitis (CP) are considered to be two separate pancreatic diseases in most studies, but some clinical retrospective analyses in recent years have found some degree of correlation between the two in actual treatment, however, the exact association is not clear. In this study, bioinformatics analysis was utilized to examine microarray sequencing data in mice, with the aim of elucidating the critical signaling pathways and genes involved in the progression from AP to CP. Differential gene expression analyses on murine transcriptomes were conducted using the R programming language and the R/Bioconductor package.
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