AI Article Synopsis
- The study examines how the subventricular zone (SVZ) behaves in a patient with frontotemporal lobar degeneration and amyotrophic lateral sclerosis (FTLD-ALS).
- An increase in Ki-67 positive cells and neuroblasts indicates heightened cell proliferation in the SVZ, possibly as a response to the neurodegeneration associated with FTLD-ALS.
- This altered neurogenesis might point to new therapeutic strategies to address neuronal loss in ALS.
Article Abstract
Investigate how the subventricular proliferation and organisation is modified in a patient with FTLD-ALS. We studied the subventricular zone (SVZ) of a patient with FTLD-ALS immunohistochemical and histologically. We found an increase of Ki-67 positive cells and neuroblast in the subventricular zone, suggesting an activation of proliferating activity in response to FTD-ALS. This proliferation can act as a compensatory mechanism for rapid neuronal death and its modulation could provide a new therapeutic pathway in ALS. These results suggest a modification of neurogenesis in FTD-ALS.
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| http://dx.doi.org/10.1016/j.neulet.2011.05.019 | DOI Listing |
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