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Imaging Findings in Acute Traumatic Brain Injury: a National Institute of Neurological Disorders and Stroke Common Data Element-Based Pictorial Review and Analysis of Over 4000 Admission Brain Computed Tomography Scans from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study.
J Neurotrauma
October 2024
Department of Radiology, Royal Perth Hospital (RPH) and University of Western Australia (UWA), Perth, Australia; Western Australia National Imaging Facility (WA NIF) node, Australia.
In 2010, the National Institute of Neurological Disorders and Stroke (NINDS) created a set of common data elements (CDEs) to help standardize the assessment and reporting of imaging findings in traumatic brain injury (TBI). However, as opposed to other standardized radiology reporting systems, a visual overview and data to support the proposed standardized lexicon are lacking. We used over 4000 admission computed tomography (CT) scans of patients with TBI from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study to develop an extensive pictorial overview of the NINDS TBI CDEs, with visual examples and background information on individual pathoanatomical lesion types, up to the level of supplemental and emerging information (e.
View Article and Find Full Text PDFDisseminated adult Wilms tumor in pregnancy: Leveraging multidisciplinary care in a low-resource setting.
Int J Gynaecol Obstet
May 2024
Department of Obstetrics & Gynecology, University of Ghana Medical School, Accra, Ghana.
Wilms tumor (WT) occurring in adults is rare and even much more rarely found to coexist with pregnancy. Clinical outcome in adults is worse overall compared with pediatric patients with WT and is often misdiagnosed with no standardized protocols for care guided by high-evidence clinical trials. We present a case of a 23-year-old woman diagnosed with WT who was found to be pregnant immediately following nephrectomy.
View Article and Find Full Text PDFA Case of Wilms Tumor in a Primary Adrenal Mature Teratoma.
Cureus
July 2023
Pathology, King Abdulaziz University, Jeddah, SAU.
We report the first known case of an adrenal teratoma containing a Wilms tumor component, in a 12-month-old girl with Trisomy 21. Despite adrenal teratomas being relatively uncommon, this particular instance raises interesting questions regarding the tumor origin, given the coexistence of both a teratoma and a Wilms tumor. Two main theories of development have been hypothesized, one of which suggests that the Wilms tumor may develop from a primary teratoma and the other proposing that the teratoma could originate from a primary Wilms tumor.
View Article and Find Full Text PDFBilateral Wilms' Tumor With Different Responses to Preoperative Chemotherapy.
Cureus
October 2022
Surgery, Umm Al-Qura University, Makkah, SAU.
Wilms' tumor (WT) is a common type of primary renal tumor in the pediatric population that can equally affect both sides. Herein, we describe a case of bilateral Wilms' tumor (BWT) in a three-year-old male with different responses to preoperative chemotherapy in the two kidneys. The left kidney mass responded poorly to chemotherapy than the right kidney, which raised the suspicion of coexisting benign disease or congenital anomaly.
View Article and Find Full Text PDFGenomic landscape of T-cell lymphoblastic lymphoma.
Chin J Cancer Res
April 2022
Department of Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Objective: T-cell lymphoblastic lymphoma (T-LBL) is an aggressive neoplasm of precursor T cells, however, detailed genome-wide sequencing of large T-LBL cohorts has not been performed due to its rarity. The purpose of this study was to identify putative driver genes in T-LBL.
Methods: To gain insight into the genetic mechanisms of T-LBL development, we performed whole-exome sequencing on 41 paired tumor-normal DNA samples from patients with T-LBL.
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