Cu(I)- and Ru(II)-mediated "click" cyclization of tripeptides toward vancomycin-inspired mimics.

Org Lett

Division of Medicinal Chemistry & Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands.

Published: July 2011

Structural mimics comprising 1,4- and 1,5-disubstituted triazole-containing cyclic tripeptides with excellent resemblance toward the DE-ring of vancomycin are conveniently accessible using Cu(I)- or Ru(II)-assisted "click" cyclization.

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Source
http://dx.doi.org/10.1021/ol201184bDOI Listing

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