Objective: Human studies have shown that electrical impedance myography (EIM), a technique based on the surface application of high-frequency, low-intensity electrical current to localized areas of muscle, is sensitive to muscle denervation. In this study, we examined the role of EIM as a potential biomarker for assessing ALS disease progression in the SOD1 transgenic rat by comparing it to motor unit number estimation (MUNE).
Methods: Multi-frequency EIM and MUNE were performed twice weekly in 16 rats from approximately 10 weeks of age onward. Four different EIM measures were evaluated, including the previously studied 50 kHz phase and three condensed multi-frequency parameters.
Results: The rate of deterioration in the multi-frequency phase data from 100-500 kHz had the strongest correlation to survival (ρ=0.79, p<0.001), surpassing that of MUNE (ρ=0.57, p=0.020). These two measures were also strongly correlated (ρ=-0.94, p<0.001) to one another.
Conclusions: These findings support that EIM is an effective tool for assessing disease progression in the ALS rat.
Significance: Given its ease of application and ability to assess virtually any superficial muscle, EIM deserves further study as a biomarker in human ALS clinical therapeutic trials.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192294 | PMC |
| http://dx.doi.org/10.1016/j.clinph.2011.04.021 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Overweight and Obese Children Aged 6-17 Years in China Had Lower Level of Hydration Status: A Cross-Sectional Study.
Nutrients
January 2025
National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing 100050, China.
Purpose: The aims of this study were to explore the differences in total body water and hydration status among Chinese children aged 6-17 years.
Methods: A cross-sectional study was implemented among children aged 6-17 years in China. The total body water (TBW), intracellular water (ICW), and extracellular water (ECW) were determined by bioelectrical impedance analysis (BIA).
Electrochemical Switching of Laser-Induced Graphene/Polymer Composites for Tunable Electronics.
Polymers (Basel)
January 2025
Research School of Chemical and Biomedical Technologies, Tomsk Polytechnic University, Lenin Ave. 30, 634050 Tomsk, Russia.
Laser reduction of graphene oxide (GO) is a promising approach for achieving flexible, robust, and electrically conductive graphene/polymer composites. Resulting composite materials show significant technological potential for energy storage, sensing, and bioelectronics. However, in the case of insulating polymers, the properties of electrodes show severely limited performance.
View Article and Find Full Text PDFField-Programmable Gate Array (FPGA)-Based Lock-In Amplifier System with Signal Enhancement: A Comprehensive Review on the Design for Advanced Measurement Applications.
Sensors (Basel)
January 2025
Facultad de Ingeniería, Universidad Autónoma de Baja California, Mexicali 21280, Mexico.
Lock-in amplifiers (LIAs) are critical tools in precision measurement, particularly for applications involving weak signals obscured by noise. Advances in signal processing algorithms and hardware synthesis have enabled accurate signal extraction, even in extremely noisy environments, making LIAs indispensable in sensor applications for healthcare, industry, and other services. For instance, the electrical impedance measurement of the human body, organs, tissues, and cells, known as bioelectrical impedance, is commonly used in biomedical and healthcare applications because it is non-invasive and relatively inexpensive.
View Article and Find Full Text PDFA Precise Oxide Film Thickness Measurement Method Based on Swept Frequency and Transmission Cable Impedance Correction.
Sensors (Basel)
January 2025
School of Information Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Accurately measuring the thickness of the oxide film that accumulates on nuclear fuel assemblies is critical for maintaining nuclear power plant safety. Oxide film thickness typically ranges from a few micrometers to several tens of micrometers, necessitating a high-precision measurement system. Eddy current testing (ECT) is commonly employed during poolside inspections due to its simplicity and ease of on-site implementation.
View Article and Find Full Text PDFOptimal Design and Operation of an Ultrasonic Driving System for Algae Removal Considering Underwater Environment Load.
Sensors (Basel)
January 2025
Department of Electric Engineering, Changwon National University, Changwon 51140, Republic of Korea.
This study investigates the optimal design and operation of an underwater ultrasonic system for algae removal, focusing on the electromechanical load of Langevin-type piezoelectric transducers. These piezoelectric transducers, which operate in underwater environments, exhibit variations in electrical-mechanical impedance due to practical environmental factors, such as waterproof molding structures or variations in pressure and flow rates depending on the water depth. To address these challenges, we modeled the underwater load conditions using the finite element method and analyzed the impedance characteristics of the piezoelectric transducer under realistic environmental conditions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!