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Use of biologics in Chinese pregnant patients with deficiency of interleukin-36 receptor antagonist (DITRA): A case series.
Taiwan J Obstet Gynecol
May 2024
Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:
Article Synopsis
- Impetigo herpetiformis (IH) is a rare and severe skin condition linked to pregnancy complications, primarily caused by a genetic defect in the IL36RN gene.
- This case series of six Chinese patients with IH during eight pregnancies explored the use of various biologics, like adalimumab, etanercept, and secukinumab, to manage their condition.
- Most patients had successful pregnancies, but one experienced fetal heart rate issues that improved after changing medications, indicating that biologics may be beneficial for treating IH in those with the genetic defect.
Identification of a new allele of BraA09g066480.3C controlling the wax-less phenotype of Chinese cabbage.
BMC Plant Biol
September 2023
Laboratory of Vegetable Genetics Breeding and Biotechnology, Department of Horticulture, Shenyang Agricultural University, No. 120 Dongling Road, Shenhe District, Shenyang, 110866, China.
Background: Epidermal wax covers the surfaces of terrestrial plants to resist biotic and abiotic stresses. Wax-less flowering Chinese cabbage (Brassica campestris L. ssp.
View Article and Find Full Text PDFStructural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex.
Nat Struct Mol Biol
June 2023
Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Article Synopsis
- Certain tRNA transcripts in bacteria, archaea, and eukarya contain introns and require splicing to become mature, with splicing in eukaryotes initiated by the TSEN complex.
- The study reports cryo-electron microscopy structures of the human TSEN-pre-tRNA complex, revealing its architecture and binding interfaces, along with features important for recognizing pre-tRNA.
- TSEN54 serves as a key scaffold in the complex, and the structures allow for visualization of mutations linked to pontocerebellar hypoplasia (PCH), shedding light on pre-tRNA splicing mechanisms and PCH-related disorders.
Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN.
Nat Struct Mol Biol
June 2023
Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt am Main, Germany.
Heterotetrameric human transfer RNA (tRNA) splicing endonuclease TSEN catalyzes intron excision from precursor tRNAs (pre-tRNAs), utilizing two composite active sites. Mutations in TSEN and its associated RNA kinase CLP1 are linked to the neurodegenerative disease pontocerebellar hypoplasia (PCH). Despite the essential function of TSEN, the three-dimensional assembly of TSEN-CLP1, the mechanism of substrate recognition, and the structural consequences of disease mutations are not understood in molecular detail.
View Article and Find Full Text PDFAn unknown essential function of tRNA splicing endonuclease is linked to the integrated stress response and intron debranching.
Genetics
May 2023
Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
tRNA splicing endonuclease (TSEN) has a well-characterized role in transfer RNA (tRNA) splicing but also other functions. For yeast TSEN, these other functions include degradation of a subset of mRNAs that encode mitochondrial proteins and an unknown essential function. In this study, we use yeast genetics to characterize the unknown tRNA-independent function(s) of TSEN.
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