Objective: To investigate the changes of the asphericity (Q-value) of the posterior corneal surface with different corneal diameters after corneal refractive surgery.
Methods: One hundred and fifteen myopic eyes of 115 subjects undertaken corneal refractive surgery (59 LASIK and 56 EPI-LASIK) were enrolled in this prospective study. The Q-value of the posterior corneal surface for patients with different corneal diameters (6, 7, 8 and 9 mm) was measured with Pentacin pre- and post-operatively. The correlations between Q-value, Q change (ΔQ), and the mean preoperative spherical equivalent refraction (SE), central corneal thickness (CCT), central ablation depth (AD) and AD/CCT were investigated.
Results: The mean Q-value of the posterior corneal surface in 115 preoperative eyes with corneal diameters at 6, 7, 8 and 9 mm was 0.08 ± 0.16, -0.05 ± 0.13, -0.15 ± 0.12 and -0.26 ± 0.11, respectively. The Q-value had a statistically significant positive shift 1 month after surgery in eyes with 6, 7 and 8 mm corneal diameters (LASIK: t(6mm) = -2.076, P = 0.042; t(7mm) = -2.873, P = 0.006; t(8mm) = -2.180, P = 0.033; EPI-LASIK: t(6mm) = -2.859, P = 0.006; t(7mm) = -3.901, P = 0.000; t(8mm) = -3.510, P = 0.001). The mean Q-value diminished significantly 6 months compared to 1 month after surgery, and had an obvious tendency back to its preoperative level. No statistically significant correlation between Q and SE or CCT was found in the preoperative eyes. Also, no correlation between ΔQ and SE, CCT, AD and AD/CCT was found after surgery.
Conclusions: The shape of the posterior corneal surface in myopic eyes was more prolate as corneal diameter increased, which was similar to the anterior corneal surface. The posterior corneal surface showed central flattening and peripheral steepening (oblate shift) at early stage either post-LASIK or post-EPI-LASIK, and then returned to its original state over time.
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Am J Pathol
December 2024
International Ocular Surface Research Center, Key Laboratory for Regenerative Medicine, Institute of Ophthalmology, Jinan University, Guangzhou 510632, China; Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou 510630, China. Electronic address:
The gut microbiota plays a crucial regulatory role in various physiological processes, yet its impact on corneal homeostasis remains insufficiently understood. Here, we investigate the effects of antibiotic-induced gut dysbiosis (AIGD) and germ-free (GF) conditions on circadian gene expression, barrier integrity, nerve density, and immune cell activity in the corneas of mice. Through RNA sequencing, we found that both AIGD and GF conditions significantly disrupted the overall transcriptomic profile and circadian transcriptomic oscillations in the cornea.
View Article and Find Full Text PDFBMC Ophthalmol
December 2024
School of Medicine, Xiamen Eye Center and Eye Institute of Xiamen University, Xiamen, 361000, China.
Purepose: The intraoperative femtosecond laser time, Cumulative Dissipated Energy (CDE), Effective Phacoemulsification time (EPT), and intraoperative fluid perfusion volume were compared under different model fragmentation modes using Catalys femtosecond laser system.
Methods: This was a single-center, prospective, randomized controlled study. A total of 120 eyes who underwent femtosecond laser-assisted cataract phacoemulsification combined with intraocular lens implantation in Xiamen Eye Center affiliated to Xiamen University from September 2022 to March 2023 were randomly divided into 4 groups to undergo pre-nucleus splitting in different ways: Group 1: six-split, Group 2: eight-split, Group 3: six-split + gridded softening, and Group 4: eight-split + gridded softening.
Cornea
October 2024
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL.
Purpose: The purpose of this study was to report the management of chemoimmunotherapy-resistant ocular surface squamous neoplasia (OSSN) with iodine-125 (I-125) brachytherapy.
Methods: A 36-year-old man presented to the clinic with biopsy-proven OSSN that covered ∼70% of the corneal surface and extended to the 6 o'clock position of the inferior limbus of the OS. The visual acuity was 20/20 in the OD and 20/40 in the affected OS.
Indian J Ophthalmol
December 2024
Department of Cornea, Gokhale Eye Hospital, Mumbai, Maharashtra, India.
Allergy is one of the most common diagnoses in an ocular surface clinic, and its treatment can range from a simple lubricant to the most complex combinations of medications belonging to several diverse classes. Antiallergics are the most commonly used medication overall in all forms of allergy. Several options are available, and it is important to understand how to start, select, and continue their use.
View Article and Find Full Text PDFGels
December 2024
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria.
The study investigates the development and characterization of dual-loaded niosomes incorporated into ion-sensitive in situ gel as a potential drug delivery platform for ophthalmic application. Cannabidiol (CBD) and epigallocatechin-3-gallate (EGCG) simultaneously loaded niosomes were prepared via the thin film hydration (TFH) method followed by pulsatile sonication and were subjected to comprehensive physicochemical evaluation. The optimal composition was included in a gellan gum-based in situ gel, and the antimicrobial activity, in vitro toxicity in a suitable corneal epithelial model (HaCaT cell line), and antioxidant potential of the hybrid system were further assessed.
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