AI Article Synopsis
- The study aims to explore the expression levels of CD10 and osteopontin in dentigerous cysts and ameloblastoma, potentially linking their expression to the neoplastic potential and invasive characteristics of these conditions.
- Methods included immunohistochemical analysis of tissue samples from 9 dentigerous cyst cases and 17 ameloblastoma cases, with statistical analysis performed using specialized software to evaluate the data.
- Results showed higher expression of CD10 and osteopontin in ameloblastoma compared to dentigerous cysts, correlating this expression with greater neoplastic potential and increased risks of local invasion and recurrence in ameloblastoma.
Article Abstract
Aims And Objectives: To investigate the expression of CD10 and osteopontin in dentigerous cyst and ameloblastoma and to correlate their expression with neoplastic potentiality of dentigerous cyst and local invasion and risk of local recurrence in ameloblastoma.
Methods: CD10 and osteopontin expression was studied by means of immunohistochemistry in 9 cases of dentigerous cysts (DC) and 17 cases of ameloblastoma. There were 7 unicystic ameloblastoma (UCA) and 10 multicystic ameloblastoma (MCA). Positive cases were included in the statistical analysis, carried on the tabulated data using the Open Office Spreadsheet 3.2.1 under Linux operating system. Analysis of variance and correlation studies were performed using "R" under Linux operating system (R Development Core Team (2010). Tukey post-hoc test was also performed as a pair-wise test. The significant level was set at 0.05.
Results: High CD10 and osteopontin expression was observed in UCA and MCA, and low CD10 and osteopontin expression was observed in DC. Significant correlation was seen between CD10 and osteopontin expression and neoplastic potentiality of DC and local invasion and risk of recurrences in ameloblastoma.
Conclusions: In DC, high CD10 and osteopontin expression may indicate the neoplastic potentiality of certain areas. In UCA & MCA, high CD10 and osteopontin expression may identify areas with locally invasive behavior and high risk of recurrence.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118315 | PMC |
| http://dx.doi.org/10.1186/1746-1596-6-44 | DOI Listing |
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