AI Article Synopsis
- SN-38 was tested on various lung cancer cell lines and showed the ability to inhibit both anchorage-dependent and -independent growth.
- It disrupts mitochondrial functions, halts cell cycle progression in S- and G2-phases, and triggers cell death through caspase 3 and PARP activation.
- A single injection of SN-38 significantly reduced lung cancer xenograft tumors, suggesting its potential as an effective treatment for lung cancer.
Article Abstract
The effect of SN-38 was evaluated on multiple lung cancer cell lines. It inhibits anchorage-dependent and -independent growth as monitored by MTT and soft agar colony assay, respectively. SN-38 collapsed the mitochondrial membrane potential (MMP), arrested cells in S- and G2-phases of the cell cycle, and induced apoptosis via activation of caspase 3 and PARP. A single injection of 2 mg/kg body weight of SN-38 caused a significant reduction of lung cancer xenografts. These findings indicate that SN-38 induces apoptosis in the lung cancer cells effectively. Thus, SN-38 can potentially be an effective therapeutic agent against lung cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133571 | PMC |
| http://dx.doi.org/10.1615/jenvironpatholtoxicoloncol.v30.i1.10 | DOI Listing |
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