Linear accelerator based intracranial and extracranial stereotactic radiation therapy at the University of Oklahoma.

Purpose: Review our institutional outcomes with linear accelerator based stereotactic radiation therapy at the University of Oklahoma.

Methods: We retrospectively reviewed all patients treated in our department with linear accelerator based stereotactic radiation therapy since we implemented this modality in 2008. Thirty-seven patients have been treated with a mean follow-up of 8.3 months. Seventeen patients had tumors near critical structures; ten had treatment sites not suited for gamma knife therapy. Outcomes are reviewed for efficacy and toxicity.

Results: Acute and long term complications reported are minimal. Stabilization of treatment sites was achieved in 96% of patients on follow-up imaging. Thirteen patients (35%) have died, of which eleven died to systemic disease progression outside of the treatment site. No treatment related deaths occurred.

Conclusions: Stereotactic radiation therapy is a successful treatment modality to achieve local disease control with minimal toxicity. We plan to expand its use and applications in the future.