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An Unusual Diagnosis of Rectosigmoid Leiomyoma in an Adult: A Rare Case Report.
Clin Med Insights Case Rep
December 2024
Department of Gastroenterology, Faculty of Medicine, University of Balamand, Beirut, Lebanon.
Leiomyomas are uncommon tumors of the gastrointestinal system, representing around 0.03% to 0.05% of all rectal tumors.
View Article and Find Full Text PDFDiagnostic Performance of Faecal Immunochemical Testing (FIT) in Patients with Lynch Syndrome Scheduled for Colonoscopic Surveillance.
Diagnostics (Basel)
October 2024
Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK.
Article Synopsis
- Lynch syndrome (LS) patients have a high risk of colorectal cancer, currently monitored through biennial colonoscopy, which can be burdensome and invasive.
- This study assessed whether faecal immunochemical testing (FIT) for faecal haemoglobin could effectively replace the need for routine colonoscopy in LS surveillance.
- Results showed FIT has low sensitivity for detecting adenomas, with no improvement when a second test was added, suggesting it may not be a viable alternative to colonoscopy.
Chronic Diarrhea Owing to Microscopic Colitis: A Cohort Study with Insights into Diagnostic Challenges and Size of the Problem.
Diagnostics (Basel)
October 2024
Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
Article Synopsis
- Microscopic colitis (MC) is a significant but often overlooked cause of chronic diarrhea, especially when colonoscopy results appear normal, prompting the need for more thorough diagnostic methods.
- A study involving 116 patients showed that 32.8% were diagnosed with MC, with lymphocytic colitis being more prevalent, and elevated inflammatory markers like fecal calprotectin, ESR, and CRP were linked to MC.
- Symptoms such as nocturnal diarrhea and abdominal pain were strongly associated with MC, and specific cutoff values for inflammatory markers demonstrated high accuracy for diagnosis, indicating the necessity for further exploration and validation in future research.
Evidence of Site-Specific Mucosal Autoantibody Secretion in Rheumatoid Arthritis.
Arthritis Rheumatol
October 2024
Leiden University Medical Center, Leiden, The Netherlands.
Objective: Anti-citrullinated protein antibodies (ACPA) have been detected in sputum and saliva, indicating that anti-modified protein antibodies (AMPA) can be produced at mucosal sites in patients with rheumatoid arthritis (RA). However, the body's largest mucosal compartment, the gut, has not yet been examined. We therefore investigated the presence of several AMPA (ACPA, anti-carbamylated protein antibodies [anti-CarP], and anti-acetylated protein antibodies [AAPA]) at different mucosal sites, including the intestinal tract.
View Article and Find Full Text PDFAcute Intestinal Obstruction in a Case of Cerebrovascular Accident.
Cureus
June 2024
Department of Medicine, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.
Ogilvie's syndrome represents an acute form of intestinal obstruction that occurs in the absence of a detectable mechanical blockage impeding fecal passage. Hence, it is also given the name of intestinal pseudo-obstruction. It has been deemed a disease of imbalance between the arms of the autonomic nervous system with an increase in parasympathetic outflow.
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