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Treatment Options for Advanced Non-Small Cell Lung Cancer After Failure of Previous Immune Checkpoint Inhibitors and Chemotherapy: Meta-Analysis of Five Randomized Controlled Trials.
Curr Oncol
January 2025
Hospital Pharmacy, Vittorio Veneto Hospital, 31029 Vittorio Veneto, Italy.
Background: Immune checkpoint inhibitors (ICIs), either alone or in combination with platinum-based chemotherapy, are effective in the first-line treatment of metastatic, non-oncogene-addicted, non-small cell lung cancer (NSCLC). However, when NSCLC patients progress, the efficacy of available treatment options is limited.
Methods: We undertook a meta-analysis that compared combination regimens with the current standard of care.
Purging the Judiciary After a Transition: Between a Rock and a Hard Place.
Hague J Rule Law
March 2024
Department of Constitutional Law and Political Science, Faculty of Law, Masaryk University, Brno, Czech Republic.
Judges play a key role in the implementation of transitional justice mechanisms. Yet, less attention has been paid so far to the question of how to address their collaboration with non-democratic regimes. In theory, judges can be subjected to virtually all transitional justice mechanisms ranging from criminal prosecution and lustration to truth-seeking, or even amnesties.
View Article and Find Full Text PDFDegeneration of the nucleus pulposus affects the internal volumetric strains and failure location of adjacent human metastatic vertebral bodies.
Acta Biomater
January 2025
Department of Industrial Engineering, Alma Mater Studiorum - University of Bologna, Via Terracini 28, 40131 Bologna, Italy. Electronic address:
Intervertebral disc (IVD) degeneration is suspected to affect the distribution of stress and strain near the vertebral endplates and in the underlying bone. This scenario is worsened by the presence of metastatic lesions on the vertebrae (primarily thoracic vertebrae (60-80 %)) which increase the risk of fracture. As such, this study aimed to evaluate the effect of IVD degeneration on the internal volumetric strains and failure modes of human metastatic vertebral bodies.
View Article and Find Full Text PDFTherapeutic Consequences and Prognostic Impact of Multimorbidity in Heart Failure: Time to Act.
J Clin Med
December 2024
Department of Adult Cardiology, Gottsegen National Cardiovascular Center, 1096 Budapest, Hungary.
: In heart failure (HF) with reduced ejection fraction (HFrEF), the early diagnosis and proper treatment of comorbidities (CMs) are of fundamental relevance. Our aim was to assess the prevalence of CMs among real-world patients requiring hospitalisation for HFrEF and to investigate the effect of CMs on the implementation of guideline-directed medical therapy (GDMT) and on all-cause mortality (ACM). : The data of a consecutive HFrEF patient cohort hospitalised for HF between 2021 and 2024 were analysed retrospectively.
View Article and Find Full Text PDFSquare Root Unscented Kalman Filter-Based Multiple-Model Fault Diagnosis of PEM Fuel Cells.
Sensors (Basel)
December 2024
Institute of Autmatic Control, University of Kaiserslautern-Landau, 67653 Kaiserslautern, Germany.
Harsh operating conditions imposed by vehicular applications significantly limit the utilization of proton exchange membrane fuel cells (PEMFCs) in electric propulsion systems. Improper/poor management and supervision of rapidly varying current demands can lead to undesired electrochemical reactions and critical cell failures. Among other failures, flooding and catalytic degradation are failure mechanisms that directly impact the composition of the membrane electrode assembly and can cause irreversible cell performance deterioration.
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