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Combining Water-Soluble Porphyrin and Phthalocyanine Photosensitizers With Doxorubicin Improves the Efficacy of Chemo-Photodynamic Therapy Against DMBA-Induced Breast Carcinoma.
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Institute of Basic and Applied Sciences, Egypt-Japan University of Science and Technology, New Borg El Arab, Alexandria, Egypt.
Breast cancer ranks as the second most widespread form of cancer globally. Currently, combination therapy is being actively employed in clinical practice to augment the efficiency of anticancer treatment. Hence, the objective of this study was to assess the therapeutic efficacy of a combination of femtosecond laser-based photodynamic therapy (PDT) utilizing two distinct photosensitizers (PSs), zinc phthalocyanine tetrasulfonate (ZnPcS) and α,β,χ,δ porphyrin-Tetrakis (1-methylpyridinium-4-yl) p-Toluenesulfonate porphyrin (TMPyP) in conjunction with doxorubicin chemotherapeutic agent, on mammary carcinomas experimentally induced in female mice using 7,12-dimethylbenz[a] anthracene (DMBA).
View Article and Find Full Text PDFA Femtosecond Fiber Laser-Based Compact Label-Free Multimodality Nonlinear Optical Microscopy and Its Ex Vivo Bioimaging.
Microsc Res Tech
December 2024
Institute of Photonics and Photon-Technology, Northwest University, Xi'an, China.
Nonlinear multimode imaging is a versatile tool to realize complex structural and compositional information of biological samples. In this study, we presented a novel integrated multimode nonlinear optical microscopy system by using an Er3 + -doped femtosecond fiber laser. The system could perform second harmonic generation (SHG), third harmonic generation (THG), and three-photon fluorescence (3PEF) imaging modes simultaneously.
View Article and Find Full Text PDFOptical excitation and detection of high-frequency Sezawa modes in Si/SiO system decorated with NiFe nanodot arrays.
Ultrasonics
November 2024
Department of Condensed Matter and Materials Physics, S. N. Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700 106, India. Electronic address:
Surface acoustic waves have emerged as one of the potential candidates for the development of next-generation wave-based information and computing technologies. For practical devices, it is essential to develop the excitation techniques for different types of surface acoustic waves, especially at higher microwave frequencies, and to tailor their frequency versus wave vector characteristics. We show that this can be done by using ultrashort laser pulses incident on the surface of a multilayer decorated with a periodic array of metallic nanodots.
View Article and Find Full Text PDFIn this paper, we present the demonstration of a cavity-dumped Kerr-lens mode-locked femtosecond oscillator based on an Yb:CALYO crystal for the first time. With the assistance of an SESAM, the Kerr-lens mode-locked Yb:CALYO laser delivered pulses with an average power of 2.8 W at a repetition rate of 61.
View Article and Find Full Text PDFEffects of femtosecond laser on hard dental tissues: A scoping review.
Lasers Med Sci
November 2024
Faculty of Medicine and Health, Sydney Dental School, The University of Sydney, Camperdown, NSW, 2006, Australia.
Article Synopsis
- Traditional tooth preparation can be uncomfortable and risky, but femtosecond lasers provide a precise, non-invasive alternative that minimizes these issues.
- This study aimed to evaluate how femtosecond laser treatment affects enamel and dentin through a review of in vitro and in vivo studies, following strict guidelines for systematic reviews.
- After a thorough literature search, 48 relevant studies were identified, focusing on the quality of tooth preparation and the effects of laser parameters, although the overall quality of these studies was not assessed.
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