Growth-factor regulation of mdm-2 messenger-RNA expression.

Oncol Rep

THOMAS JEFFERSON UNIV,JEFFERSON CANC INST,PHILADELPHIA,PA 19107. IST REGINA ELENA,ONCOGENESI MOLEC LAB,ROME,ITALY.

Published: July 1994

We have investigated the growth factor regulation of mdm-2 mRNA levels in mouse embryo fibroblasts, whose growth is controlled by platelet-derived growth factor (PDGF) and insulin-like growth factor I (IGF-I). We find that both growth factors up-regulate the expression of mdm-2 mRNA, independently of each other.

Download full-text PDF

Source
http://dx.doi.org/10.3892/or.1.4.695DOI Listing

Publication Analysis

Top Keywords

growth factor
12
regulation mdm-2
8
mdm-2 mrna
8
growth
5
growth-factor regulation
4
mdm-2 messenger-rna
4
messenger-rna expression
4
expression investigated
4
investigated growth
4
factor regulation
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!