AI Article Synopsis

  • Scientists are studying how the autonomic nervous system affects the immune system, especially in diseases like rheumatoid arthritis (RA).
  • They found that RA patients often have an unbalanced nervous system, with less activity from the calming side and more from the exciting side.
  • Researchers believe that changing how the nervous system works could help reduce inflammation and lead to new treatments for RA.

Article Abstract

The immunomodulatory effect of the autonomic nervous system has raised considerable interest over the last decades. Studying the influence on the immune system and the role in inflammation of the sympathetic as well as the parasympathetic nervous system not only will increase our understanding of the mechanism of disease, but also could lead to the identification of potential new therapeutic targets for chronic immune-mediated inflammatory diseases, such as rheumatoid arthritis (RA). An imbalanced autonomic nervous system, with a reduced parasympathetic and increased sympathetic tone, has been a consistent finding in RA patients. Studies in animal models of arthritis have shown that influencing the sympathetic (via α- and β-adrenergic receptors) and the parasympathetic (via the nicotinic acetylcholine receptor α7nAChR or by electrically stimulating the vagus nerve) nervous system can have a beneficial effect on inflammation markers and arthritis. The immunosuppressive effect of the parasympathetic nervous system appears less ambiguous than the immunomodulatory effect of the sympathetic nervous system, where activation can lead to increased or decreased inflammation depending on timing, doses and kind of adrenergic agent used. In this review we will discuss the current knowledge of the role of both the sympathetic (SNS) and parasympathetic nervous system (PNS) in inflammation with a special focus on the role in RA. In addition, potential antirheumatic strategies that could be developed by targeting these autonomic pathways are discussed.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188868PMC
http://dx.doi.org/10.2119/molmed.2011.00065DOI Listing

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