A fully automated and GMP compatible synthesis has been developed to reliably label the M₁ receptor agonist GSK1034702 with carbon-11. Stille reaction of the trimethylstannyl precursor with [¹¹C]methyl iodide afforded [¹¹C]GSK1034702 in an estimated 10 ± 3% decay corrected yield. This method utilises the commercially available modular laboratory equipment and provides high purity [¹¹C]GSK1034702 in a formulation suitable for human use.
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| http://dx.doi.org/10.1016/j.apradiso.2011.05.007 | DOI Listing |
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