A strategy for the stepwise annulation of pyrrolic rings of a porphyrin to imidazole rings is presented. Mono(imidazole), Janus and corner bis(imidazole), T-shaped tris(imidazole), and tetrakis(imidazole) porphyrins have been synthesized and characterized.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol2010215 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Thermal Resistance Enhancement and Wettability Amelioration of Poly(benzimidazole-aramid) Film by Silica Nanocomposites.
Polymers (Basel)
December 2024
Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology (JAIST), 1-1 Asahidai, Nomi 923-1292, Japan.
Polybenzimidazole (PBI) is a high-performance polymer known for its excellent thermal stability, mechanical strength, and chemical resistance, attributes that are derived from its unique structure comprising repeated benzene and imidazole rings. However, limitations such as relatively low thermal stability and moisture sensitivity restrict its application as a super engineering plastic. In this study, amide groups are incorporated into the PBI backbone to synthesize the copolymer poly(BI--A), effecting a structural modification at the molecular level.
View Article and Find Full Text PDFA Newly Synthesized Benzimidazolium Salt: 1-(2-Cyanobenzyl)-3-(4-Vinylbenzyl)-1H-Benzo[D]imidazol-3-ium Chloride as a Potential Anticancer Agent for Colon Cancer Treatment, In Vitro Study.
J Biochem Mol Toxicol
January 2025
Department of Medical Biology, Faculty of Medicine, Erciyes University, Kayseri, Türkiye.
Colon cancer is one of the most common cancer-related deaths. Drug resistance is one of the biggest challenges in cancer treatment. Numerous pharmacological and biochemical investigations have documented the benzimidazole ring's anticancer, anti-inflammatory, and antioxidant properties.
View Article and Find Full Text PDFIntramolecular Inhibition by Imidazole in Acid-Catalyzed Hydrolysis of Protected Carbohydrates.
Chemistry
December 2024
Eotvos Lorand University, Organic Chemistry, Pazmany Peter Setany 1/A, 1117, Budapest, HUNGARY.
The present study reveals an unexpected anomaly observed in the acid-catalyzed hydrolysis of the 5,6-O-isopropylidene group in 3-O-protected D-gluco- and D-allofuranose derivatives. Although the removal of the 5,6-O-isopropylidene protecting group is typically rapid and quantitative under acidic conditions, an unexpected inhibition of this reaction is observed for the two C3-epimers, 3-O-imidazole sulfonyl moiety. X-ray data show a two-faced imidazole ring orientation in the crystal, while solution state NOE data reveal a critical interaction type between the isopropylidene and the imidazole rings.
View Article and Find Full Text PDFSystematic Analysis of the Effect of Benzene on the Corrosion Inhibition Performance of Imidazoline Derivatives: Experimental and Theoretical Research.
Langmuir
December 2024
State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu 610500, Sichuan, P. R. China.
Imidazoline derivatives are widely used to prevent corrosion due to their toxicity and mitigation potential. The present study deals with the synthesis of two imidazole Schiff derivatives (JSMP and JSPP) based on imidazole hexanoate (JSMZ). The corrosion mitigation potential and mechanism in 1.
View Article and Find Full Text PDFCircumventing Imatinib resistance in CML: Novel Telmisartan-based cell death modulators with improved activity and stability.
Eur J Med Chem
February 2025
Department of Internal Medicine V, Hematology and Oncology, Tyrolean Cancer Research Institute (TKFI), Comprehensive Cancer Center Innsbruck (CCCI), Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria. Electronic address:
Drug resistance presents a significant challenge in cancer therapy, which has led to intensive research in resistance mechanisms and new therapeutic strategies. In chronic myeloid leukemia (CML), the introduction of Imatinib, the first tyrosine kinase inhibitor (TKI), drastically changed the outcome for patients. However, complete remission still cannot be achieved in a large number of patients in the long term.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!