Streptococcus salivarius exhibited an anti-inflammatory effect on intestinal epithelial cells (IECs) and monocytes. Strains were screened using a reporter clone, HT-29/kB-luc-E, induced by tumor necrosis factor alpha (TNF-α). Supernatant from each strain downregulated NF-κB activation. The two most efficient strains produced an active metabolite (<3 kDa) which was able to downregulate the secretion of the proinflammatory chemokine interleukin-8 (IL-8).
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127691 | PMC |
| http://dx.doi.org/10.1128/AEM.03021-10 | DOI Listing |
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