An adaptive step length estimation algorithm operating with optimal parameters and a movement status awareness algorithm are proposed. The proposed algorithm was developed as a means for increasing the accuracy in estimating walking distances. The algorithm was applied to pedestrian navigation system, ubiquitous health monitoring systems, and so forth. The algorithm's optimal parameters were derived after measurement errors were taken into consideration. The movement status awareness algorithm was designed using a walking characteristic called the acceleration variance. After estimating a subject's walking distance using the proposed algorithm, the measured error was 4.8% with respect to actual walking distance. Alternatively, estimating a subject's walking distance without the algorithm yielded an error of 20% with respect to actual walking distance.
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http://dx.doi.org/10.1016/j.medengphy.2011.04.009 | DOI Listing |
Objective: This study aimed to assess the effect of home-based exercise interventions on walking performance in patients with peripheral artery disease (PAD) and intermittent claudication (IC).
Design: Systematic review and meta-analysis.
Data Sources: We searched the Medline, Web of Science, Embase, Scopus and Cochrane Library databases to identify randomised controlled trials of patients with PAD and IC published in English up to August 2024.
J Appl Biomech
January 2025
Department of Health and Kinesiology, The University of Utah, Salt Lake City, UT, USA.
Shoes or insoles embedded with carbon fiber materials to increase longitudinal stiffness have been shown to enhance running and walking performance in elite runners, and younger adults, respectively. It is unclear, however, if such stiffness modifications can translate to enhanced mobility in older adults who typically walk with greater metabolic cost of transport compared to younger adults. Here, we sought to test whether adding footwear stiffness via carbon fiber insoles could improve walking outcomes (eg, distance traveled and metabolic cost of transport) in older adults during the 6-minute walk test.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of California Irvine, Irvine, CA, USA.
Background: Alterations to spatial navigation have been suggested by previous studies to represent an early cognitive marker for those with and at risk of Alzheimer's Disease (AD). However, with most of these studies focusing on spatial memory (usage of formed spatial representations), very little is known about the extent to which spatial exploration (process by which spatial representations are formed) may be altered in AD. The aim of this study is to investigate how spatial exploration behavior may be altered in individuals with and at risk of AD, and the extent to which individuals can be classified into their clinical status based on their exploration behavior.
View Article and Find Full Text PDFMol Ther
January 2025
Institute of Experimental Medicine CAS, Department of Neuroregeneration, Videnska 1083, 142 20, Prague, Czech Republic. Electronic address:
Neurons in the central nervous system (CNS) lose regenerative potential with maturity, leading to minimal corticospinal tract (CST) axon regrowth after spinal cord injury (SCI). In young rodents, knockdown of PTEN, which antagonises PI3K signalling by hydrolysing PIP3, promotes axon regeneration following SCI. However, this effect diminishes in adults, potentially due to lower PI3K activation leading to reduced PIP3.
View Article and Find Full Text PDFJ Chem Inf Model
January 2025
Department of Computer Science and Technology, Shantou University, Shantou 515063, China.
The human microbiota may influence the effectiveness of drug therapy by activating or inactivating the pharmacological properties of drugs. Computational methods have demonstrated their ability to screen reliable microbe-drug associations and uncover the mechanism by which drugs exert their functions. However, the previous prediction methods failed to completely exploit the neighborhood topologies of the microbe and drug entities and the diverse correlations between the microbe-drug entity pair and the other entities.
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