[The correlation between hyperinsulinemia and pulse wave velocity].

Objective: To study the correlation between hyperinsulinemia (HIns) and arteriosclerosis in one community in Beijing.

Methods: Subjects who received arteriosclerosis screening in physical examination annually were studied. All subjects were received 75g oral glucose tolerance test (OGTT) to evaluate glucose metabolic level, and brachial-ankle pulse wave velocity (baPWV) examination to evaluate arteriosclerosis. The correlation between hyperinsulinemia and pulse wave velocity was analyzed.

Results: Among all the 1046 subjects under investigation, baPWV of subjects with HIns was higher than subjects with normoinsulinemic (NIns) in different glucose metabolism status [normal glucose tolerance, (1381.2 ± 280.8) cm/s vs (1280.3 ± 218.7) cm/s; imparied glucose regulation, (1557.5 ± 319.3) cm/s vs (1474.7 ± 305.1) cm/s; diabetes, (1764.3 ± 476.6) cm/s vs (1664.2 ± 374.6) cm/s], especially in subjects with normal glucose tolerance (P < 0.01). The prevalence of cardiovascular risk factors in subjects with HIns was much higher than subjects with NIns (P < 0.01). Multiple logistic regression analysis showed that hyperinsulinemia was the risk factor of arteriosclerosis, and the OR (95%CI) of subjects with HIns was 1.91 (1.169 - 3.105, P < 0.01) as compared to the subjects with NIns.

Conclusion: The subjects with HIns suffered from much more metabolic risk factors than NIns. Hyperinsulinemia that closely correlated with baPWV was a risk factor of arteriosclerosis.