Background: Bitter cumin (Centratherum anthelminticum (L.) Kuntze), is a medicinally important plant. Earlier, we have reported phenolic compounds, antioxidant, and anti-hyperglycemic, antimicrobial activity of bitter cumin. In this study we have further characterized the antioxidative activity of bitter cumin extracts in various in vitro models.
Methods: Bitter cumin seeds were extracted with a combination of acetone, methanol and water. The antioxidant activity of bitter cumin extracts were characterized in various in vitro model systems such as DPPH radical, ABTS radical scavenging, reducing power, oxidation of liposomes and oxidative damage to DNA.
Results: The phenolic extracts of bitter cumin at microgram concentration showed significant scavenging of DPPH and ABTS radicals, reduced phosphomolybdenum (Mo(VI) to Mo(V)), ferricyanide Fe(III) to Fe(II), inhibited liposomes oxidation and hydroxyl radical induced damage to prokaryotic genomic DNA. The results showed a direct correlation between phenolic acid content and antioxidant activity.
Conclusion: Bitter cumin is a good source of natural antioxidants.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112436 | PMC |
| http://dx.doi.org/10.1186/1472-6882-11-40 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Antioxidant and anti-inflammatory activities of Centratherum anthelminticum (L.) Kuntze seed oil in diabetic nephropathy via modulation of Nrf-2/HO-1 and NF-κB pathway.
BMC Complement Med Ther
November 2022
Department of Biochemistry, University of Karachi, Karachi, Pakistan.
Background: Type 2 diabetes mellitus (T2DM) approximately constitutes 90% of the reported cases. 30-40% of diabetics eventually develop diabetic nephropathy (DN); accounting for one of the major causes of morbidity and mortality. Increased glucose autoxidation and non-enzymatic glycation of proteins in diabetic kidneys lead to the excessive generation of reactive oxygen species (ROS) that results in lipid peroxidation and activation of inflammatory mediators which overwhelms the scavenging capacity of the antioxidant defense system (Nrf2/Keap1/HO-1).
View Article and Find Full Text PDFVirtual screening of functional foods and dissecting their roles in modulating gene functions to support post COVID-19 complications.
J Food Biochem
December 2021
Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong, Bangladesh.
COVID-19 has become the focal point since 2019 after the outbreak of coronavirus disease. Many drugs are being tested and used to treat coronavirus infections; different kinds of vaccines are also introduced as preventive measure. Alternative therapeutics are as well incorporated into the health guidelines of some countries.
View Article and Find Full Text PDFIntercrop mulch affects soil biology and microbial diversity in rainfed transgenic Bt cotton hybrids.
Sci Total Environ
November 2021
Division of Crop Production, ICAR-Central Institute for Cotton Research, Nagpur 440010, Maharashtra, India.
Growing live mulch between the wide-row spaced transgenic Bt cotton hybrids is a low-cost option to control weeds compared to the use of plastic mulch. However, nothing is known about their effects on soil biology. Therefore, soil samples were collected from a long-term field study (2014-15 to 2018-19) to investigate the soil biological activities as well as the microbial diversity (soil metagenomic analysis).
View Article and Find Full Text PDFA Survey on Chemical Constituents and Indications of Aromatic Waters Soft Drinks (Hydrosols) Used in Persian Nutrition Culture and Folk Medicine for Neurological Disorders and Mental Health.
J Evid Based Complementary Altern Med
October 2017
1 Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
In Persian nutrition culture, drinking aromatic waters (hydrosols, distillate) has a long history as functional beverages or therapeutic remedies. The co-distilled water with essential oils, which contains partial amounts of more water-soluble volatile compounds are diluted and used as beverages. Since the solubility of volatile components is different in water, the overall composition, and thus the biological activities of aromatic waters seem to be different from the essential oils they were co-distilled with.
View Article and Find Full Text PDFElucidation of molecular targets of bioactive principles of black cumin relevant to its anti-tumour functionality - An Insilico target fishing approach.
Bioinformation
December 2014
Department of Biotechnology, PES Institute of Technology, Bangalore, India ; Department of Biotechnology, PES Institute of Technology, Bangalore, India.
Black cumin (Nigella sativa) is a spice having medicinal properties with pungent and bitter odour. It is used since thousands of years to treat various ailments, including cancer mainly in South Asia and Middle Eastern regions. Substantial evidence in multiple research studies emphasizes about the therapeutic importance of bioactive principles of N.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!