AI Article Synopsis
- The functional lumen imaging probe (FLIP) was evaluated for its ability to assess structural changes at the gastroesophageal junction (GEJ) after transoral incisionless fundoplication (TIF).
- In the study, both animal models and human patients underwent FLIP measurements alongside other testing methods, showing a significant initial decrease in the cross-sectional area (CSA) of the GEJ post-TIF, but a return to baseline at 2 weeks in animals.
- The results indicate that FLIP effectively measures GEJ distensibility and correlates with traditional testing methods, suggesting its potential as a diagnostic tool for GERD and evaluation after antireflux surgery.
Article Abstract
Background: The functional lumen imaging probe (FLIP) uses impedance planimetry to measure the geometry of a distensible organ. The purpose of this study was to evaluate FLIP as a method to determine structural changes at the gastroesophageal junction (GEJ) following transoral incisionless fundoplication (TIF) and compare these findings with the accepted methods of esophageal testing.
Methods: Two different approaches (TIF1.0 and 2.0) using the EsophyX™ device were performed in six and five animals, respectively. Three dogs underwent a sham procedure. FLIP measurements were performed pre- and post-procedure and at 2-week follow-up. Upper endoscopy, manometry, and 48-h pH testing were also performed at each time point. FLIP was performed in ten patients before and 3 months after TIF.
Results: Following TIF procedures, there was a significant decrease in cross-sectional area (CSA) of GEJ compared to baseline; however, the CSA of both groups returned to baseline at 2-week follow-up. The FLIP results were supported with pH testing and correlated highly with both measures of GEJ structural integrity (LES and cardia circumference). Following TIF in humans, there was a decrease in GEJ distensibility compared to baseline that persisted to the 3-month evaluation.
Conclusion: FLIP is able to measure and display changes in tissue distensibility at the GEJ, and results correlate with established methods of testing. FLIP may represent a single testing modality by which to diagnose GERD and evaluate the outcome after antireflux surgery.
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| http://dx.doi.org/10.1007/s11605-011-1562-2 | DOI Listing |
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