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Optimizing encephalomyocarditis virus VP1 protein assembly on pseudorabies virus envelope via US9 protein anchoring.
Virulence
December 2025
The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China.
Live herpesvirus-vectored vaccines are critical in veterinary medicine, but they can sometimes offer insufficient protection due to suboptimal antigen expression or localization. Encephalomyocarditis virus (EMCV) is a significant zoonotic threat, with VP1 protein as a key immunogen on its capsid. To enhance immunogenicity, we explored the use of recombinant pseudorabies virus (rPRV) as a vaccine vector against EMCV.
View Article and Find Full Text PDFDevelopment of a water-dispersible antimicrobial lipid mixture to inhibit African swine fever virus and other enveloped viruses.
Virus Res
January 2025
Natural Biologics Inc., Newfield, NY 14867, USA. Electronic address:
Medium-chain antimicrobial lipids are promising antiviral agents to inhibit membrane-enveloped viruses such as African swine fever virus (ASFV) and influenza A virus (IAV) in livestock applications. However, current uses are limited to feed pathogen mitigation due to low aqueous solubility and the development of water-dispersible lipid formulations is needed for broader application usage. In this study, we report a water-dispersible antimicrobial lipid mixture of monoglycerides and lactylates that can inhibit ASFV and IAV and exhibits antiviral properties in drinking water and feed matrices.
View Article and Find Full Text PDFPorcine astrovirus 3 RNA in the central nervous system of weaned pigs with neurologic disease and polioencephalomyelitis in Brazil.
Microb Pathog
November 2024
Laboratory of Animal Virology, Department of Preventive Veterinary Medicine, Universidade Estadual de Londrina, Londrina, Paraná, Brazil; Multi-User Animal Health Laboratory, Molecular Biology Unit, Department of Preventive Veterinary Medicine, Universidade Estadual de Londrina, Paraná, Brazil. Electronic address:
Article Synopsis
- * Three piglets, aged 20-35 days old, were examined post-mortem after showing signs of neurological disease, leading to the identification of significant damage in the grey matter of their spinal cords and brainstems.
- * This marks the first documented case of PAstV3 in piglets with neurological disorders in Brazil, emphasizing the need for continued monitoring of health issues that could affect pig farming efficiency and animal welfare.
The complex interplay between encephalomyocarditis virus and the host defence system.
Virulence
December 2024
Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou, China.
A variety of animals can be infected by encephalomyocarditis virus (EMCV). EMCV is the established causative agent of myocarditis and encephalitis in some animals. EMCV causes high fatality in suckling and weaning piglets, making pigs the most susceptible domestic animal species.
View Article and Find Full Text PDFThe Reproduction Number of Swine Viral Respiratory Diseases: A Systematic Review.
Vet Sci
July 2024
Department of Veterinary Integrative Biosciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.
Diseases in the swine industry can cause significant economic and health impacts. This review examines R estimates for respiratory diseases in pigs, assessing variations and comparing transmission risks within and between farms. A literature search of three databases aggregated peer-reviewed research articles on swine viral respiratory diseases' R values.
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