The recent improvement in radiation techniques and the associated significant prolongation of survival have resulted in a widespread utilization of mediastinal irradiation in patients with various neoplasms. However, a large number of experimental and clinical studies have clearly demonstrated that high-dose therapeutic mediastinal irradiation can produce delayed, severe cardiovascular disease. This review presents the data from the Literature regarding the pathogenesis, pathology, prevalence and clinical manifestation of the radiation-related heart disease.
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