A family of six novel p-hydroxyacetophenone amides, 1-6, was isolated from Cystobacter ferrugineus, strain Cb G35. Their structures were elucidated by ESI-TOF mass spectrometry and NMR spectroscopy. Feeding experiments with labeled [¹³C₉,¹⁵N]-tyrosine and [d₁₀]-leucine identified the biosynthetic precursors of 1.
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http://dx.doi.org/10.1021/np1006789 | DOI Listing |
ChemSusChem
November 2023
Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, United Kingdom.
Scalable processes have been developed to convert β-pinene into 4-isopropenylcyclohexanone, which is then used as a feedstock for the divergent synthesis of sustainable versions of the common painkillers, paracetamol and ibuprofen. Both synthetic routes use Pd catalysed reactions to aromatize the cyclohexenyl rings of key intermediates to produce the benzenoid ring systems of both drugs. The potential of using bioderived 4-hydroxyacetophenone as a drop-in feedstock replacement to produce sustainable aromatic products is also discussed within a terpene biorefinery context.
View Article and Find Full Text PDFNat Prod Res
September 2019
b Sorbonne Universités, UPMC Univ Paris 06, CNRS, Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), Observatoire Océanologique , Banyuls-sur-Mer , France.
A new alkaloid, (10, 12)-9-ureidooctadeca-10, 12-dienoic acid, named oleraurea and 10 known compounds, -hydroxybenzaldehyde , -hydroxybenzoic acid , -hydroxyacetophenone , benzamide , (--coumaramide , ()-ferulamide , soyalkaloid A , -carboline-3-carboxylic acid , 2, 3, 4, 9-tetrahydro--pyrido [3, 4-] indole-3-carboxylic acid , (1, 3)-1-methyl-1, 2, 3, 4-tetrahydro--carboline-3-carboxylic acid were obtained from L., in which, compounds , , were isolated from the plant for the first time. The structure of the compound was identified using spectroscopic methods including 1D and 2D NMR, HR-ESI-TOF-MS.
View Article and Find Full Text PDFBioorg Med Chem
February 2018
National Center for Natural Products Research, Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Fusarithioamide B (6), a new aminobenzamide derivative with unprecedented carbon skeleton and five known metabolites: stigmast-4-ene-3-one (1), stigmasta-4,6,8(14),22-tetraen-3-one (2), p-hydroxyacetophenone (3), tyrosol (4), and fusarithioamide A (5) were separated from Fusarium chlamydosporium EtOAc extract isolated from Anvillea garcinii (Burm.f.) DC.
View Article and Find Full Text PDFBioresour Technol
June 2012
Department of Aquatic Biosciences, National Chiayi University, 300 University Rd., Chiayi 60004, Taiwan.
In this study, the transformation of sulfonamide antibiotics (SAs, 50 mg L(-1)) was investigated in systems consisting of a fungal laccase (6 IU) and six mediators (1mM). The results illustrate that the laccase had limited effect on the removal of sulfadimethoxine and sulfamonomethoxine. However, laccase oxidation with the mediators (LMS) led to significant declines of the SAs.
View Article and Find Full Text PDFJ Nat Prod
June 2011
Research Group Microbial Drugs, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
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