In the title compound, C(17)H(20)N(2)O(4), the 2,5-dimeth-oxy-phenyl unit is essentially planar, with an r.m.s. deviation of 0.015 Å. The dihedral angle between the benzene rings is 43.66 (4)°. The mol-ecular structure is stabilized by a short intra-molecular N-H⋯O hydrogen bond. In the crystal, inter-molecular N-H⋯O and O-H⋯O hydrogen bonds link the mol-ecules into a three-dimensional network.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007839 | PMC |
| http://dx.doi.org/10.1107/S1600536810033520 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A machine learning-based model for predicting the risk of cognitive frailty in elderly patients on maintenance hemodialysis.
Sci Rep
January 2025
School of Nursing, Chengdu Medical College, Chengdu, China.
Elderly patients undergoing maintenance hemodialysis (MHD) face a heightened risk of cognitive frailty (CF), which significantly compromises quality of life. Early identification of at-risk individuals and timely intervention are essential. Nevertheless, current CF risk prediction models fall short in accuracy to adequately fulfill clinical requirements.
View Article and Find Full Text PDFDesign, synthesis, biological evaluation, kinetic studies and molecular modeling of imidazo-isoxazole derivatives targeting both α-amylase and α-glucosidase inhibitors.
Heliyon
October 2024
Department of Chemistry, College of Science, Qassim University, Buraidah, 51452, Saudi Arabia.
Herein, a novel set of imidazo-isoxazole derivatives containing thiourea and urea scaffolds were synthesized, characterized (H NMR, C NMR, and elemental analysis). These compounds were biologically evaluated for their α-amylase and α-glucosidase inhibitory activity, identifying as the most active (IC 26.67 ± 1.
View Article and Find Full Text PDFInhibition of soluble epoxide hydrolase reverses bone loss in periodontitis by upregulating EMCN and inhibiting osteoclasts.
Stem Cell Res Ther
November 2024
School of Stomatology, Dalian Medical University, Dalian, 116044, China.
Background: Improving the microenvironment to augment endogenous regenerative potential has emerged as a fundamental concept for stimulating and expediting periodontal tissue repair and regeneration. Previous studies have demonstrated that TPPU, a soluble epoxide hydrolase inhibitor (sEHi), mediates the suppression of inflammatory bone loss in periodontitis models. However, the underlying mechanisms remain largely elusive.
View Article and Find Full Text PDFPhase I-IV Drug Trials on Hepatocellular Carcinoma in Asian Populations: A Systematic Review of Ten Years of Studies.
Int J Mol Sci
August 2024
Department of Anatomy and Cell Biology, College of Medicine, Gachon University, 155 Getbeol-ro, Yeonsu-gu, Incheon 21999, Republic of Korea.
Article Synopsis
- Despite advancements in treating hepatocellular carcinoma (HCC), options for patients remain limited, with HCC being the most common liver cancer globally.
- A systematic review of clinical trials from 2013 to 2023 identified 60 relevant studies on current treatments for HCC in Asian populations, focusing on pharmacological interventions and surgical options.
- The review highlights that sorafenib, either used alone or in combination with other drugs like atezolizumab and bevacizumab, has been the preferred treatment choice over the past decade for better patient outcomes.
Characterizing Growth-Retarded Japanese Eels (): Insights into Metabolic and Appetite Regulation.
Metabolites
August 2024
China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology (Shanghai), Shanghai Ocean University, Shanghai 201306, China.
During field surveys and culture procedures, large growth disparities in have been observed. However, the potential causes are unknown. This study explored differences in digestive ability, metabolic levels, and transcriptomic profiles of appetite-related genes between growth-retarded eel (GRE) and normal-growing eel (NGE) under the same rearing conditions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!