In the title compound, C(18)H(13)N(3)O, the diaza-fluorene ring system is almost coplanar (r.m.s. deviation = 0.0640 Å) and subtends an angle of 61.5 (4)° with the plane of the meth-oxy-substituted benzene ring. In the crystal structure, pairs of C-H⋯O hydrogen bonds link mol-ecules into centrosymmetric dimers parallel to the ab plane. Mol-ecules are also stacked in an obverse fashion along the c axis by a variety of π-π inter-actions with centroid-centroid distances in the range 3.557 (2)-3.921 (2) Å.
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http://dx.doi.org/10.1107/S1600536810023275 | DOI Listing |
Chem Biodivers
January 2025
Chuxiong Normal University, Academy of Science and Technology, Chuxiong Normal University, Chuxiong, 675000,China, No. 456 Luchengnan Road, chuxiong, Academy of Science and Technology, 651000, chuxiong, CHINA.
Gray mold disease is caused by B. cinerea, which could severely reduce the production yield and quality of tomatoes. To explore more potential fungicides with new scaffolds for controlling the gray mold disease, ten aldehydes-thiourea derivatives were designed, synthesized and assayed for inhibitory activity against three plant pathogenic fungi.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
January 2025
Boston College, William F. Connell School of Nursing, Boston, MA, United States.
Background: The effect of antidiabetic agents on mortality outcomes is unclear for individuals with diabetes mellitus (DM) who are hospitalized for COVID-19.
Purpose: To examine the relationship between antidiabetic agent use and clinical outcomes in individuals with DM hospitalized for COVID-19.
Methods: A systematic review of the literature (2020-2024) was performed across five databases.
Cureus
December 2024
Department of Anaesthesiology, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.
Introduction Spinal anesthesia, a commonly used technique for lower abdominal, pelvic, and lower extremity surgeries, involves injecting a local anesthetic into the subarachnoid space to temporarily block sensory, motor, and sympathetic nerves. Despite its high success rate, the failure of spinal anesthesia, which can lead to adverse patient outcomes, remains a concern. The failure rate varies widely, from 1% to 17%, influenced by factors such as technical challenges, patient anatomy, and practitioner experience.
View Article and Find Full Text PDFCureus
December 2024
Ophthalmology, SightMD, Babylon, USA.
Dupilumab is a monoclonal antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling and is used in the treatment of moderate-to-severe atopic dermatitis (AD) in those six months or older who are uncontrolled on or cannot tolerate topical treatments. Ocular surface disease is a recognized adverse effect of dupilumab, yet few studies describe the risk factors for developing ocular adverse effects. There are no standardized recommendations for monitoring patients on this medication.
View Article and Find Full Text PDFCureus
December 2024
Obstetrics and Gynecology, ESI Hospital and Postgraduate Institute of Medical Sciences and Research (PGIMER) Basaidarapur, New Delhi, IND.
Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality. Early prediction is the need of the hour so that interventions like aspirin prophylaxis can be started. Nowadays, machine learning (ML) is increasingly being used to predict the disease and its prognosis.
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