The title compound, C(9)H(11)NO(3), was prepared by an Aldol reaction of 2,3-dihydro-1H-pyrrolizin-1-one with formaldehyde. The asymmetric unit contains six mol-ecules. The pyrrolizine ring system in each mol-ecule is planar, the maximum atomic deviation being 0.066 (2) Å. In the crystal structure, mol-ecules are liked together by an extensive O-H⋯O hydrogen-bonding network.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006763PMC
http://dx.doi.org/10.1107/S1600536810018970DOI Listing

Publication Analysis

Top Keywords

22-bishy-droxy-meth-yl-23-dihydro-1h-pyrrolizin-1-one title
4
title compound
4
compound c9h11no3
4
c9h11no3 prepared
4
prepared aldol
4
aldol reaction
4
reaction 23-dihydro-1h-pyrrolizin-1-one
4
23-dihydro-1h-pyrrolizin-1-one formaldehyde
4
formaldehyde asymmetric
4
asymmetric unit
4

Similar Publications

Systematic Literature Review of Access Pathways to Drugs for Patients with Rare Diseases.

Appl Health Econ Health Policy

December 2024

Centre for Health Economics Research and Evaluation, University of Technology Sydney, Level 5, Building 20, 100 Broadway, Chippendale, Sydney, NSW, 2008, Australia.

Objective: This article reviews the assessment pathways that have been implemented worldwide to facilitate access to drugs for patients with rare diseases.

Methods: The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were used to conduct a systematic literature review. The Ovid (Embase/MEDLINE), Cochrane, Web of Science, Econlit, National Institute of Health Research, Centre for Reviews and Dissemination, and International Network of Agencies for Health Technology Assessment databases were searched.

View Article and Find Full Text PDF

Tranexamic acid in hip and spine surgery for children with cerebral palsy - a PRISMA-compliant scoping review.

Syst Rev

December 2024

Department of Paediatrics, The Royal Children's Hospital, University of Melbourne, 50 Flemington Road, Parkville, VIC, 3052, Australia.

Many children with cerebral palsy (CP) are frail and require major hip and/or spine surgeries associated with substantial blood loss. Tranexamic acid (TXA) is commonly used to reduce blood loss, but there is uncertainty around the optimal dose and timing of administration. There have been reviews in sub-populations and specific dosing regimens, but a broad overview of the available literature is lacking.

View Article and Find Full Text PDF

On September 23-24 (2024) the 6th Workshop IRE on Translational Oncology, titled "Cancer Organoids as Reliable Disease Models to Drive Clinical Development of Novel Therapies," took place at the IRCCS Regina Elena Cancer Institute in Rome. This prominent international conference focused on tumor organoids, bringing together leading experts from around the world.A central challenge in precision oncology is modeling the dynamic tumor ecosystem, which encompasses numerous elements that evolve spatially and temporally.

View Article and Find Full Text PDF

Background: Parkinson's disease (PD) is a neurodegenerative disorder that affects millions of people worldwide. Mobile technologies enable Parkinson's patients to improve their quality of life, manage symptoms, and enhance overall well-being through various applications (apps). There is no integrated list of specific capabilities available to cater to the unique needs of Parkinson's patient-focused mobile apps.

View Article and Find Full Text PDF

Factors associated with patients' demand for low-value care: a scoping review.

BMC Health Serv Res

December 2024

Department of Health Economics and Health Services Research, National Institute for Public Health and the Environment (RIVM), P.O. Box 13720, Antonie van Leewenhoeklaan 9, Bilthoven, BA, Netherlands.

Background: Low-value care is unnecessary care that contributes to inefficient use of health resources and constitutes a considerable proportion of healthcare expenditures worldwide. Factors contributing to patients' demand for low-value care have often been overlooked and are dispersed in the literature. Therefore, the current study aimed to systematically summarize factors associated with patients' demand for low-value care.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!