One hundred and four subjects with heroin dependence, consecutive new admission to a ward were studied prospectively to assess treatment retention. All these subjects were admitted voluntarily after pre-admission counselling wherein treatment package (four week's stay), ward routine, rules and regulation were explained. Socio-demographic parameters, drug use history, motivation as understood by "readiness to change", reasons for seeking treatment were obtained. Reasons for non completion were noted. Thirty two subjects (31%) completed treatment. Out of 72 non-completers, 38 subjects (36%) left against medical advice and 34(33%) were discharged prematurely by the treating team for violating ward norms. Multivariate analysis showed that readiness to change (being in action stage), age of onset of heroin use (late), legal problems (high) and self confidence regarding recovery (high) in order of significance, predicted treatment completion. Therapeutic strategies to minimise drop-out. are discussed.
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J Voice
January 2025
UCSF Voice and Swallowing Center, Department of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California. Electronic address:
Objective: Current literature involving gender-affirming voice therapy (GAVT) for transgender and nonbinary (TGNB) individuals is limited. This study describes treatment duration and satisfaction at a single institution.
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J Orthop Sci
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Cell Therapy and Experimental Surgery of Musculoskeletal System LR18SP11 Lab, Faculty of Medicine, Sfax, Tunisia; Department of Orthopedics and Traumatology, CHU Habib Bourguiba, Sfax, Tunisia.
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Med Intensiva (Engl Ed)
January 2025
Pulmonary and Critical Care Division, University Hospital of Federal University of Juiz de Fora, Brazil; School of Medicine, Federal University of Juiz de Fora, Minas Gerais, Brazil. Electronic address:
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Eur J Surg Oncol
December 2024
Department of Anatomy, Medicine and Surgery, University of Malta, Msida, MSD2080, Malta.
Introduction: Current trends of delaying childbearing and the increasing incidence of endometrial cancer in nulliparous woman necessitate research and development of fertility sparing treatments. Hormonal therapy with progestins offers an alternative to surgical treatment for a select group of patients of reproductive-age, who wish to preserve their reproductive potential.
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Zhonghua Xue Ye Xue Za Zhi
December 2024
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 301600, China.
Minimal residual disease (MRD), a crucial biomarker for assessing efficacy and predicting recurrence, refers to residual tumor cells remaining in the body of patients with hematological malignancies who achieved complete remission after treatment. This study aimed to conduct a retrospective analysis of the clinical diagnosis, treatment, and MRD monitoring of a pediatric patient with multiple acute B-lymphocytic leukemia relapses, alongside a review of relevant literature. In this case, Ig rearrangement based on next-generation sequencing (NGS) was more accurate in assessing the MRD level, compared with the traditional method of MRD detection, indicating the risk of earlier relapse and guided interventions in time.
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