In the title compound, C(24)H(17)ClN(6), the dihedral angles between the triazolyl ring and its adjacent chlorobenzene and trisubstituted benzene rings are 90.6 (2) and 55.7 (3)°, respectively. The dihedral angle between the trisubstituted ring and the attached tolyl ring of the biphenyl unit is 45.9 (3)°. Intra- and intermolecular N-H⋯N hydrogen bonds are present.
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http://dx.doi.org/10.1107/S1600536809014032 | DOI Listing |
J Exp Clin Cancer Res
December 2024
Scientific Direction, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
On September 23-24 (2024) the 6th Workshop IRE on Translational Oncology, titled "Cancer Organoids as Reliable Disease Models to Drive Clinical Development of Novel Therapies," took place at the IRCCS Regina Elena Cancer Institute in Rome. This prominent international conference focused on tumor organoids, bringing together leading experts from around the world.A central challenge in precision oncology is modeling the dynamic tumor ecosystem, which encompasses numerous elements that evolve spatially and temporally.
View Article and Find Full Text PDFInorg Chem
December 2024
Institute of Inorganic Chemistry (IAC), Karlsruhe Institute of Technology (KIT), Engesserstraße 15, D-76131 Karlsruhe, Germany.
Crown-ether coordination compounds of europium(II/III) and the crown ether (CHO) (24-crown-8, 24c8) are prepared, aiming at novel compounds, structures, and coordination modes as well as potential luminescence properties. By reacting EuCl, EuI, or EuCl with 24c8 or its derivatives in ionic liquids, the novel compounds [BuMeN][Eu(II)(NTf)] (), [BMIm][EuI] (), [EuCl(dibenzo-18c6)] (), [EuI(dibenzo-24c8)] (), [(Eu(III)Cl)(CHO)](24c8) (), and [Eu(III)Cl(24c8)]I () are obtained (BMIm: 1-butyl-3-methylimidazolium; EMIm: 1-ethyl-3-methylimidazolium). Based on different reaction conditions, different coordinative modes including the absence of the crown ether in the product (, ), splitting of the crown ether (), and coordination of 24c8 via six of eight oxygen atoms () and, finally, via all oxygen atoms () are observed.
View Article and Find Full Text PDFArch Pharm (Weinheim)
January 2025
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
New derivatives 6a-m with benzimidazole-indole-amide scaffold were developed, synthesized, and assessed for potential inhibitory effects on α-glucosidase and acetylcholinesterase (AChE). These compounds were synthesized by various amine derivatives. With the exception of two compounds, the α-glucosidase inhibitory activities of the title derivatives were more than that of the positive control acarbose.
View Article and Find Full Text PDFEFSA J
December 2024
Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Facultad de Farmacia Universidad de Sevilla Sevilla Spain.
Lately, the entire society's focus has turned towards consuming more natural food products and the production of chemicals obtained utilising green technologies. The use of chemicals as food additives is a concern for consumers. For this reason, the search for natural and more sustainable additives is a key step to control food risks while meeting consumers' requirements.
View Article and Find Full Text PDFIUCrdata
October 2024
Nelson Mandela University, Summerstrand Campus, Department of Chemistry, University Way, Summerstrand, PO Box 77000, Port Elizabeth, 6031, South Africa.
The title compound, CHO, is an α-hy-droxy-carb-oxy-lic acid whose ortho-rhom-bic polymorph has been reported earlier [Qiu (2007 ▸). , , 1819-1824]. The asymmetric unit contains two complete mol-ecules.
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