THE STRUCTURE OF ABACAVIR (SYSTEMATIC NAME: {(1S,4R)-4-[2-amino-6-(cyclo-propyl-amino)-9H-purin-9-yl]cyclo-pent-2-en-1-yl}methanol), C(14)H(18)N(6)O·2.5CH(3)OH, consists of hydrogen-bonded ribbons which are further held together by additional hydrogen bonds involving the hydroxyl group and two N atoms on an adjacent purine. The asymmetric unit also contains 2.5 mol-ecules of methanol solvate which were grossly disordered and were excluded using SQUEEZE subroutine in PLATON [Spek, (2009 ▶). Acta Cryst. D65, 148-155].
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http://dx.doi.org/10.1107/S1600536809027743 | DOI Listing |
AAPS J
January 2021
Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Alcohol dehydrogenases (ADHs) are most known for their roles in oxidation and elimination of ethanol. Although less known, ADHs also play a critical role in the metabolism of a number of drugs and metabolites that contain alcohol functional groups, such as abacavir (HIV/AIDS), hydroxyzine (antihistamine), and ethambutol (antituberculosis). ADHs consist of 7 gene family numbers and several genetic polymorphic forms.
View Article and Find Full Text PDFPharmacognosy Res
January 2018
Department of Pharmacognosy, Royal College of Pharmaceutical Education and Research, Nasik, Maharashtra, India.
Objective: A simple rapid, accurate, precise, and reproducible validated reverse phase high performance liquid chromatography (HPLC) method was developed for the determination of Abacavir (ABAC) and Lamivudine (LAMI) in bulk and tablet dosage forms.
Methods: The quantification was carried out using Symmetry Premsil C18 (250 mm × 4.6 mm, 5 μm) column run in isocratic way using mobile phase comprising methanol: water (0.
J Chromatogr B Analyt Technol Biomed Life Sci
March 2013
Department of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands.
This paper describes the development and validation of an assay for the simultaneous quantification of the antiviral and antiretroviral drugs zidovudine, abacavir, emtricitabine, lamivudine, tenofovir and ribavirin in human plasma using liquid chromatography coupled to tandem mass spectrometry. Sample pretreatment consisted of protein precipitation with 0.1% (v/v) formic acid in methanol, evaporation and reconstitution.
View Article and Find Full Text PDFSci Pharm
December 2012
Analytical Research, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Bollaram road, Miyapur, Hyderabad-500049 (AP), India. ; Department of Chemistry, Andhra University, Visakhapatnam-530003, India.
A novel, stability-indicating UHPLC method was developed for the quantitative determination of Abacavir sulfate, its related substances, and forced degradation impurities in bulk drugs. The chromatographic separation was achieved on a Waters Acquity BEH C(8), 50 mm × 2.1 mm, 1.
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