The title compound, C(24)H(12)BrCl(2)NO(4), was synthesized from 2-amino-3-bromo-1,4-naphthoquinone and 2-chloro-benzoyl chloride. The crystal structure shows that each of the chloro-phenyl rings is inclined at about 60° to the naphthoquinone ring system. The two chloro-phenyl rings adopt a conformation that ensures that chlorine substituents are anti so as to reduce electronic repulsion. An examination of the packing shows close O⋯Br and Cl⋯Cl contacts of 2.947 (2) and 3.346 (1) Å, respectively. In addition, the molecules are linked by weak intermolecular C-H⋯O and C-H⋯Cl interactions.
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http://dx.doi.org/10.1107/S1600536808039214 | DOI Listing |
Acta Crystallogr E Crystallogr Commun
October 2024
In the title mol-ecule, CHClNO, the 2-chloro-phenyl group is disordered to a small extent [occupancies 0.875 (2)/0.125 (2)].
View Article and Find Full Text PDFActa Crystallogr E Crystallogr Commun
December 2023
Department of Chemistry, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India.
In the title compound, CHClNO, the seven-membered 1,4-diazepane ring adopts a chair conformation while the 4-chloro-phenyl substituents adopt equatorial orientations. The chloro-phenyl ring at position 7 is disordered over two positions [site occupancies 0.480 (16):0.
View Article and Find Full Text PDFActa Crystallogr E Crystallogr Commun
June 2022
Department of Chemistry, M.M.A.M.C (Tribhuvan University), Biratnagar, Nepal.
In the title compound, CHClNOS, the thia-zole ring subtends dihedral angles of 13.12 (14) and 43.79 (14) ° with the attached chloro-phenyl and phenyl rings, respectively.
View Article and Find Full Text PDFInt J Mol Sci
November 2021
Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.
Selective estrogen receptor modulators (SERMs) act as estrogen receptor (ERα) agonists or antagonists depending on the target issue. Tamoxifen (TAM) (a non-steroidal triphenylethylene derivative) was the first SERM approved as anti-estrogen for the treatment of metastatic breast cancer. On the hunt for novel SERMs with potential growth inhibitory activity on breast cancer cell lines yet no potential to induce endometrial carcinoma, we designed and synthesized 28 novel TAM analogs.
View Article and Find Full Text PDFActa Crystallogr E Crystallogr Commun
September 2021
Department of Chemistry, Baku State University, Z. Khalilov str. 23, Az, 1148 Baku, Azerbaijan.
The mol-ecular conformation of the title compound, CHClNO, is stabilized by an intra-molecular O-H⋯O hydrogen bond, forming an (6) ring motif. The central pyridine ring is almost planar [maximum deviation = 0.074 (3) Å].
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