In the title compound, C(20)H(14)FN(3), the pyrimidine ring adopts a half-chair conformation. The dihedral angle between the benzimidazole ring system and the fluoro-phenyl ring is 84.18 (10)°. In the crystal structure, mol-ecules are linked into a two-dimensional network parallel to the bc plane by N-H⋯N and C-H⋯F hydrogen bonds.
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http://dx.doi.org/10.1107/S1600536808031875 | DOI Listing |
Chin Clin Oncol
October 2024
Department of Pharmacology, School of Pharmacy, Gannan Medical University, Ganzhou Cancer Precision Medicine Engineering Research Center, Ganzhou, China.
Beilstein J Org Chem
March 2024
Faculty of Natural Sciences and Technology, Riga Technical University, P. Valdena Str. 3, Riga, LV-1048, Latvia.
2-Chloro-4-sulfonylquinazolines undergo functional group swap when treated with an azide nucleophile: 1) the azide replaces the sulfonyl group at the C4 position; 2) the intrinsic azide-tetrazole tautomeric equilibrium directs the nucleofugal sulfinate from the first step to replace chloride at the C2 position. This transformation is effective with quinazolines bearing electron-rich substituents. Therefore, the title transformations are demonstrated on the 6,7-dimethoxyquinazoline core, which is present in pharmaceutically active substances.
View Article and Find Full Text PDFChem Asian J
March 2024
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388 120, Gujarat, India.
An unprecedented meglumine-based three-component deep eutectic solvent (3c-DES) (MegPAc) was synthesized using meglumine, p-toluenesulfonic acid (PTSA), and acetic acid as a renewable, and non-toxic solvent. The exploitation of the MegPAc as an eco-friendly reaction media to construct a selective and sensitive small organic molecular sensing probe, namely, pyrazolo[5,1-b]quinazoline-3-carboxylates (PQCs) was executed. Captivatingly, the MegPAc served the dual role of solvent and catalyst, and it delivered the title components with 69-94 % yields within 67-150 minutes.
View Article and Find Full Text PDFJ Chromatogr Sci
January 2025
Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Punjab 160 062, India.
Cancer is considered a silent killer. The complexity of cancer makes it earn that title. So far there are only a few approaches to treat cancer.
View Article and Find Full Text PDFJ Biomol Struct Dyn
August 2024
Department of Earth Resources and Environmental Engineering, Hanyang University, Seoul, Republic of Korea.
Two new quinazoline derivatives (2a and 2b) were successfully synthesized in this work using the condensation technique in excellent yields. Using spectroscopic techniques and elemental analyses, the compounds were completely characterized. Density functional theory (DFT) computations have been used to examine the title compound's reactive characteristics.
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