In the title hydrated mol-ecular salt, C(6)H(7)ClN(+)·C(2)HO(4) (-)·0.5H(2)O, the water O atom lies on a crystallographic twofold axis. In the crystal, the anions are linked by O-H⋯O hydrogen bonds, forming chains propagating along the b axis. These chains are inter-connected through O-H⋯O hydrogen bonds from the water mol-ecules and N-H⋯O hydrogen bonds from the cations, building layers parallel to the ab plane.
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http://dx.doi.org/10.1107/S160053681001144X | DOI Listing |
JACS Au
December 2024
Freie Universität Berlin, Physics Department, Experimental Molecular Biophysics, Arnimallee 14, 14195 Berlin, Germany.
Vibrational Stark effect (VSE) spectroscopy has become one of the most important experimental approaches to determine the strength of noncovalent, electrostatic interactions in chemistry and biology and to quantify their influence on structure and reactivity. Nitriles (C≡N) have been widely used as VSE probes, but their application has been complicated by an anomalous hydrogen bond (HB) blueshift which is not encompassed within the VSE framework. We present an empirical model describing the anomalous HB blueshift in terms of H-bonding geometry, i.
View Article and Find Full Text PDFBiochem Res Int
December 2024
Kentucky College of Osteopathic Medicine, University of Pikeville, Pikeville 41501, Kentucky, USA.
Alzheimer's disease (AD), a neurological disorder, is one of the major reasons for memory loss in the world. AD is characterized by a sequela of cognitive and functional decline caused by brain cell degeneration. Paeoniflorin is a monoterpenoid glycoside found in plants of the Paeoniaceae family, which are known for their medicinal properties including dementia.
View Article and Find Full Text PDFACS Cent Sci
December 2024
Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Prodrug-based nanoassemblies are promising platforms for cancer therapy. Prodrugs typically consist of three main components: drug modules, intelligent response modules, and modification modules. However, the available modification modules are usually hydrophobic aliphatic side chains, which affect the activation efficiency of the prodrugs.
View Article and Find Full Text PDFInt J Pharm
December 2024
School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China. Electronic address:
The coamorphous formulations have attracted increasing interest due to enhanced solubility and bioavailability, together with synergistic pharmacological effects. In this study, a ternary coamorphous system of polyphenols was successfully prepared, wherein baicalein (Bai) and resveratrol (Res) were constructed into a single-phase coamorphous system mediated by piperine (Pip). FTIR and ss C NMR spectra together with quantum chemical calculation and molecular dynamics simulation suggested Pip as a molecular bridge connected Bai and Res molecules through π-π stacking and hydrogen bonding interactions.
View Article and Find Full Text PDFJ Control Release
December 2024
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China; State Key Laboratory of Transvascular Implantation Devices, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address:
Restenosis, the re-narrowing of blood vessels after drug-coated balloons (DCBs), remains a major clinical issue. While rapamycin is the current clinical option for preventing restenosis due to its effectiveness and low toxicity, its delivery is limited by poor tissue absorption and rapid clearance, leading to suboptimal drug retention. Here, we developed the adhesive-polyelectrolyte-coated poly(lactic-co-glycolic acid) (PLGA) particles using in-situ UV-triggered polymerization, encapsulating rapamycin.
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