The dithio-carbamate anions in the title compound, [Sn(C(6)H(5))(2)(C(5)H(10)NS(2))(2)], chelate to the Sn(IV) atom, which is six-coordinated in a skew-trapezoidal-bipyramidal geometry. The mol-ecule lies across a twofold rotation axis.
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http://dx.doi.org/10.1107/S1600536810007415 | DOI Listing |
Cell Physiol Biochem
October 2017
Department of Nephropathy, Xi'an, China.
Background/aims: Diabetic nephropathy (DN) is a microangiopathic disease characterized by excessive urinary albumin excretion, which occurs in 30% of patients with diabetes mellitus. It is the second leading cause of end-stage renal diseases in China. Nuclear factor-kappa B (NF-κB) is reported to be closely correlated with the inflammation underlying diabetes-associated renal damage.
View Article and Find Full Text PDFAsian Pac J Cancer Prev
February 2017
Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran E-mail :
Previous studies suggested that dithio-carbamates are potent apoptosis and anti-apoptosis inducing agents in various cancer cells. Here, the anti-proliferative and apoptosis inducing effects of a new derivative (2-NDC) from the dithio-carbamate family was examined in human leukemia K562 cells. We use thiazolyl blue tetrazolium bromide (MTT) to measure viability and cell growth inhibition.
View Article and Find Full Text PDFActa Crystallogr E Crystallogr Commun
September 2015
Department of Chemistry, Kulliyyah of Science, International Islamic University Malaysia, 25200 Kuantan, Malaysia.
The title compound, C14H19NS2, crystallizes in the thione form with the presence of a C=S bond. The piperidine ring adopts a chair conformation. The dihedral angle between the essentially planar di-thio-carbamate and p-tolyl fragments is 74.
View Article and Find Full Text PDFPLoS One
January 2016
Biotechnology Branch, University Institute of Engineering & Technology, Panjab University, Chandigarh, India; Centre for Stem Cell & Tissue Engineering, Panjab University, Chandigarh, India.
The Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) represent family of structurally-related eukaryotic transcription factors which regulate diverse array of cellular processes including immunological responses, inflammation, apoptosis, growth & development. Increased expression of NF-kB has often been seen in many diverse diseases, suggesting the importance of genomic deregulation to disease pathophysiology. In the present study we focused on acute kidney injury (AKI), which remains one of the major risk factor showing a high rate of mortality and morbidity.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
September 2014
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, Wales.
In the title compound, C17H27N3OS2, the amide group is approximately coplanar with the pyridine ring [dihedral angle = 1.6 (1)°], whereas the di-thio-carbamate group is nearly perpendicular to the pyridine ring [dihedral angle = 76.7 (1)°].
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