In the title compound, C(42)H(46)N(2)O(4), both crystallographically independent mol-ecules display a 1,3-alternate conformation. Their crystal packing is stabilized by non-classical C-H⋯N hydrogen bonds. The dihedral angles between the planes of the aromatic rings and the mean plane through the methyl-ene C atoms bridging the aromatic rings are 78.10 (13), 80.74 (14), 81.89 (12) and 79.05 (14)° for the first mol-ecule, and 71.65 (11), 76.60 (13), 77.97 (14) and 74.76 (13)° for the second mol-ecule. Both mol-ecules have three C atoms of one prop-oxy chain disordered over two set of sites; the site-occupancy factors are 0.7/0.3 and 0.6/0.4, respectively.
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http://dx.doi.org/10.1107/S1600536810002242 | DOI Listing |
J Hazard Mater
January 2025
Department of Civil & Environmental Engineering, University of Pittsburgh, 3700 O'Hara St., Pittsburgh, PA 15261, USA; Department of Environmental and Occupational Health, University of Pittsburgh, 3700 O'Hara St., Pittsburgh, PA 15261, USA. Electronic address:
Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals used extensively across industries, including semiconductor manufacturing. Semiconductors are ubiquitous, and there is increasing global demand for semiconductors, e.g.
View Article and Find Full Text PDFJ Chromatogr A
January 2025
Analytical Chemistry Laboratory, Gembloux Agro-Bio Tech, University of Liège, Passage des Déportés 2, Gembloux 5030, Belgium. Electronic address:
The analysis of mineral oil aromatic hydrocarbons (MOAH) in vegetable oils is currently associated with high uncertainty due to various factors ranging from sample preparation to data interpretation. One significant factor is the coelution of biogenic compounds of terpenic origin with the MOAH fraction during chromatographic analysis. The common purification method is epoxidation, a chemical reaction that changes the polarity of the interferences, allowing their separation from MOAH.
View Article and Find Full Text PDFComput Biol Chem
January 2025
Drug Discovery and Development Laboratory (DDD Lab), Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address:
Multiple myeloma (MM) is the second most frequently diagnosed hematological malignancy, presenting limited treatment options with no curative potential and significant drug resistance. Recent studies involving genetic knockdown established the crucial role of GRK6 in upholding the viability of MM cells, emphasizing the need to identify potential inhibitors. Computational exploration of GRK6 inhibitors has not been attempted previously.
View Article and Find Full Text PDFJ Phys Chem Lett
January 2025
Department of Chemistry, Anhui University, Hefei 230601, P. R. China.
Despite being studied for almost two centuries, aromaticity has always been a controversial concept. We previously proposed a unified aromatic rule for π-conjugated systems by two-dimensional (2D) superatomic-molecule theory, where benzenoid rings are treated as period 2 2D superatoms (3π-N, 4π-O, 5π-F, 6π-Ne) and, further, bond to form 2D superatomic molecules. Herein, to build a 2D periodic table, we further extend the theory to period 3 (7π-P, 8π-S, 9π-Cl, 10π-Ar) and period 1 (1π-H, 2π-He) elements.
View Article and Find Full Text PDFChem Commun (Camb)
January 2025
Department of Chemical and Pharmaceutical Sciences, CENMAT, Centre of Excellence for Nanostructured Materials, INSTM UdR Trieste, University of Trieste, via Licio Giorgieri 1, 34127 Trieste, Italy.
In this work, the synthesis of an -monoarylated dihydrophenazine is reported together with its interconversion to its oxidized mono-cationic form. While the reduced state was employed for the dechlorination of aromatic substrates, the oxidized mono-cationic one was exploited for the formation of C-N bonds between aryl rings and azoles, which was achieved with high yields and very low catalyst loadings (down to 0.5 mol%).
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