The title compound, [Au(C(9)H(9)ClNOS)(C(18)H(33)P)], features a slightly distorted linear coordination geometry for the Au atom defined by a S,P-donor set [S-Au-P = 177.62 (5)°]. The distortion is ascribed to the close approach of the O atom, which forms an intra-molecular contact of 2.970 (5) Å. Disorder was found in the structure with two positions of equal weight being resolved for the C atoms comprising the eth-oxy group.
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http://dx.doi.org/10.1107/S160053681001189X | DOI Listing |
Chemosphere
January 2025
Faculty of Engineering, Hokkaido University, N13W8, Sapporo, 060-8628, Japan. Electronic address:
Global concern regarding transformation products (TPs) derived from contaminants, including pesticides, in the environment and during water treatment has been growing markedly. In the present study, we investigated the anti-acetylcholinesterase (AChE) activity of an aqueous solution of the organophosphorus insecticide disulfoton, a toxicological endpoint for determining the acceptable daily intake of disulfoton, both in the presence and the absence of metabolism during chlorination. Disulfoton rapidly reacted with free chlorine and completely disappeared within 0.
View Article and Find Full Text PDFToxicol Res (Camb)
February 2025
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India.
Objective: Organophosphorus Nerve Agent, VX [(O-Ethyl S-diisopropylaminomethyl) methylphosphonothioate] compound interferes with acetylcholine signaling by targeting the AChE enzyme. Studies suggest that in nerve agents poisoning, non-cholinergic effects are also responsible for damage in peripheral tissues including long term damage in brain. Present study reports cholinergic and non-cholinergic effects of VX poisoning and their prevention by use of N-acetylcysteine (NAC) in addition to conventional antidotes atropine sulphate and 2-PAM chloride as an antioxidant.
View Article and Find Full Text PDFFree Radic Biol Med
January 2025
Department of Analytical Chemistry, Medical University of Białystok, Mickiewicza 2D, 15-222, Białystok, Poland. Electronic address:
The lack of effective protection against UVB radiation, that severely disrupts the metabolism of keratinocytes, underlines the search for bioactive compounds that would provide effective protection without causing side effects. Therefore, the aim of the study has been to assess the effect of two compounds, that are different in terms of structure and properties: 3-O-ethyl ascorbic acid-EAA (a stable derivative of vitamin C) and cannabigerol-CBG, used separately or concurrently, on the metabolism of keratinocytes previously exposed to UVB. The obtained results indicate diverse, yet mutually reinforcing localization of the tested compounds, both within the membrane structures and cytosol.
View Article and Find Full Text PDFMolecules
December 2024
Syensqo, Centre de Recherche et Innovation Aubervilliers, 52 Rue de la Haie Coq, 93308 Aubervilliers Cedex, France.
Rhodixan A1 is the trade name for -ethyl -(1-methoxycarbonylethyl)dithiocarbonate, a RAFT/MADIX agent used by Syensqo to produce block copolymer additives for aqueous formulations on an industrial scale. Chain transfer coefficients to Rhodixan A1 determined for 25 different styrenic, acrylate, and acrylamide monomers were relatively low (0.6 < C < 3.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
Department of Physical Chemistry and Biophysics, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wrocław, Poland.
is one of the most common dermatological diseases and is strongly connected with the pathological growth of the . More than half of the cultures of this bacterium are resistant to antibiotics, resulting in the proposal of the use of antibacterial peptides as an alternative to traditional antibiotics. Ascorbic acid (AA) and its antioxidant properties may ally in acne therapy.
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